Post Operative Pain Clinical Trials

106 recruitingLast updated: June 17, 2026

There are 106 actively recruiting post operative pain clinical trials across 24 countries. Studies span Not Applicable, Phase 4, Phase 2, Phase 3, Early Phase 1, Phase 1. Top locations include Toronto, Ontario, Canada, Montreal, Quebec, Canada, Boston, Massachusetts, United States. Updated daily from ClinicalTrials.gov.


Post Operative Pain Trials at a Glance

106 actively recruiting trials for post operative pain are listed on ClinicalTrialsFinder across 6 cities in 24 countries. The largest study group is Not Applicable with 57 trials, with the heaviest enrollment activity in Toronto, Montreal, and Boston. Lead sponsors running post operative pain studies include Ain Shams University, Armed Forces Institute of Dentistry, Pakistan, and Medical University of South Carolina.

Browse post operative pain trials by phase

Treatments under study

About Post Operative Pain Clinical Trials

Looking for clinical trials for Post Operative Pain? There are currently 83 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Post Operative Pain trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Post Operative Pain clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 106 trials

Recruiting
Phase 2

Perioperative Vitamin C to Reduce Persistent Pain After Total Knee Arthroplasty

Post Operative PainChronic PainKnee Pain Chronic
University Health Network, Toronto400 enrolled3 locationsNCT06123715
Recruiting
Not Applicable

Outcomes of Pulpotomy and Root Canal Treatment in Teeth With Symptomatic Irreversible Pulpitis

Post Operative PainPulpitis - IrreversibleSuccess Rate
Mustafa Kemal University99 enrolled1 locationNCT07375576
Recruiting
Phase 4

Opioid Use After Laparoscopic Salpingectomy

Opioid UsePost Operative PainSterility, Female
Johns Hopkins University38 enrolled1 locationNCT06434233
Recruiting
Phase 1Phase 2

Intra-nasal Ketorolac for Acute Ureteral Stent-associated Pain Following Ureteroscopy for Stone Disease

Post Operative PainUrolithiasisStent Complication+1 more
University of Texas Southwestern Medical Center80 enrolled1 locationNCT06158620
Recruiting

Understanding the Acute Pain Phenotype in Patients Undergoing Surgery

Opioid UseAcute PainChronic post operative pain
Brigham and Women's Hospital1,000 enrolled1 locationNCT06466941
Recruiting
Phase 3

Suzetrigine-enhanced MultimOdal Opioid-sparing THerapy in Cardiac and Bariatric SURGery

Post Operative PainBariatric SurgeryCardiac Surgery With Sternotomy
Icahn School of Medicine at Mount Sinai235 enrolled1 locationNCT07539623
Recruiting
Not Applicable

Modulation of Periapical Inflammation Following Nano-sized Intracanal Medication. A Randomized Controlled Clinical Trial

Post Operative PainPeriapical Inflammation
Al-Azhar University63 enrolled1 locationNCT07571837
Recruiting

PAIN OUT: Improvement in Postoperative PAIN OUTcome

Post Operative Pain
University of Jena200,000 enrolled1 locationNCT02083835
Recruiting

Longitudinal Study of Chronic Postsurgical Pain in Children and Adolescents

Chronic post operative pain
Helen Koechlin281 enrolled3 locationsNCT05816174
Recruiting
Not Applicable

Comparison of Serratus Intercostal Plane Blcok With Erector Spinae Plane Block for Open Nephrectomy

Post Operative PainOpen Nephrectomy
Fayoum University Hospital132 enrolled1 locationNCT07556536
Recruiting
Not Applicable

The Analgesic Efficacy of M-TAPA for Laparoscopic Abdominal Surgery in Children

Post Operative Pain
Kasr El Aini Hospital60 enrolled1 locationNCT07540689
Recruiting

Comparison of Analgesic Efficacy of Suprainguinal Fascia Iliaca and Quadro-iliac Blocks in Hip Fracture Surgery

Post Operative Pain
Hitit University70 enrolled1 locationNCT07546903
Recruiting
Phase 3

Suzetrigine for Treatment and Reduction of Intense Discomfort After knEe Replacement PAIN

Total knee replacement surgeryPost Operative Pain
Icahn School of Medicine at Mount Sinai235 enrolled1 locationNCT07548385
Recruiting
Phase 2

Presacral Nerve Block Versus Sham Block on Post-operative Pain for Total Laparoscopic Hysterectomy

Post Operative Pain
Mount Sinai Hospital, Canada60 enrolled1 locationNCT05953766
Recruiting
Not Applicable

The Benefits Of Cryoablation In Patients Undergoing Total Knee Arthroplasty

Post Operative PainTotal Knee Arthroplasty
NYU Langone Health215 enrolled1 locationNCT06991231
Recruiting
Not Applicable

Dextromethorphan for Treatment of Postoperative Pain

Post Operative Pain
Nathanael Heckmann160 enrolled1 locationNCT05278494
Recruiting
Phase 1Phase 2

Comparison Between Tranversus Abdominis Plane (TAP) Block With Only Bupivacaine and TAP Block With Bupivacaine Plus Ketamine in Reducing Postoperative Pain After Total Abdominal Hystrectomy

Post Operative Pain in Total Abdominal Hystrectomy
Liaquat National Hospital & Medical College30 enrolled1 locationNCT07482709
Recruiting

A Multicenter Patient Registry on Outcomes From Cryoanalgesia of the Intercostal Nerves

Post Operative Pain
AtriCure, Inc.5,000 enrolled11 locationsNCT05110989
Recruiting
Not Applicable

Evaluating Postoperative Pain and Antibacterial Effect of Ultrasonic and 980 nm Diode Laser Combination

Post Operative Pain
Al-Azhar University120 enrolled1 locationNCT07041736
Recruiting
Not Applicable

Evaluation of Postoperative Pain Control in Ear Surgery

Post Operative PainAnalgesia
Kocaeli University56 enrolled1 locationNCT06869967