RecruitingNCT05683093

Cardiovascular Longitudinal ALSPAC Research Investigations Following Hypertensive Pregnancy in Young Adulthood

Cardiovascular Longitudinal the Avon Longitudinal Study of Parents and Children (ALSPAC) Research Investigations Following Hypertensive Pregnancy in Young Adulthood

Sponsor

University of Oxford

Enrollment

200 participants

Start Date

Nov 17, 2022

Study Type

OBSERVATIONAL

Conditions

Cardiovascular Diseases Hypertension Young Adult Vascular Diseases Cerebrovascular Diseases Hypertension in Pregnancy

Summary

The purpose of this study is to understand more about why young people who were born to a hypertensive pregnancy may have increased risk of high blood pressure and are often at increased risk of heart and blood vessel disease later in life.

Eligibility

Min Age: 30 YearsMax Age: 40 Years

Plain Language Summary

Simplified for easier understanding

This study — called CLARIFY — is following up on young adults who participated in the ALSPAC study (a long-running health study in the UK) to examine how having high blood pressure during pregnancy affects heart and blood vessel health years later. Researchers will conduct heart imaging and other tests to track cardiovascular risk over time. **You may be eligible if...** - You are aged 30 to 40 years old - You previously participated in the ALSPAC study - You can understand spoken and written English - You are willing and able to attend study visits **You may NOT be eligible if...** - You are currently pregnant or breastfeeding, or are less than 6 months postpartum - You are planning to donate blood within 2 weeks of your first study visit - You have a significant ongoing disease that may affect your ability to participate - You have congenital heart disease or other major cardiovascular or metabolic conditions Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERHistory of being born to hypertensive or normal pregnancy

CLARITY is an observational study whereby participants will attend one 4-hr visit the Division of Cardiovascular Medicine, University of Oxford at the John Radcliffe Hospital in Oxford, with the option to split the study visit over two days for convenience. Participants will be invited by the ALSPAC study team to attend a study visit in Oxford where the investigators will use MRI and other imaging modalities to study the brain, heart, liver, kidneys, and vasculature using standardised protocols. A dataset including information from previous follow-up of these cohorts and the detailed pregnancy data available within ALSPAC will be generated by the study team in Bristol and integrated with available data from the Oxford cohorts.