Adenovirus Mediated Suicide Gene Therapy With Radiotherapy in Progressive Astrocytoma.

This study tests a combination of gene therapy and radiation for people with brain tumors called high-grade astrocytomas (including glioblastoma) that have grown back after initial treatment. A specially engineered virus is injected into the tumor during surgery to help destroy cancer cells alongside radiation. **You may be eligible if...** - You are 18 or older - You have a high-grade astrocytoma or glioblastoma that has regrown after prior radiation and chemotherapy - At least 3 months have passed since your last radiation treatment - Your tumor can be surgically removed or debulked again - Your general functioning is reasonably good (Karnofsky score ≥ 60) - You have not previously received gene therapy, viral therapy, or brain implants for this tumor **You may NOT be eligible if...** - You have had prior gene therapy or viral therapy for any brain tumor - Your tumor is directly connected to the brain ventricles (fluid-filled spaces) - You have an immune system disorder or are on immunosuppressive drugs - Your organ function does not meet minimum requirements - You cannot consent or meet all study requirements Talk to your doctor to see if this trial is right for you.