RecruitingNCT05697926
Preclinical Research for Personalized TCR-T Therapy for Head and Neck Cancer
Sponsor
Eye & ENT Hospital of Fudan University
Enrollment
100 participants
Start Date
Mar 1, 2023
Study Type
OBSERVATIONAL
Conditions
Summary
This study will obtain tumor samples from patients with head and neck cancers and aims to develop personalized TCR-T therapy for head and neck cancer by determining the reactive TCR clone sequences in head and neck cancer.
Eligibility
Min Age: 18 YearsMax Age: 75 Years
Inclusion Criteria5
- Gender is not limited, age 18-75 years old;
- Estimated survival is greater than 3 months;
- Newly diagnosed patients with head and neck cancer without any treatment, or patients with refractory recurrent advanced head and neck cancer for which there is no available effective treatment;
- Patients with head and neck cancer whose tumor tissue can be surgically harvested;
- Volunteer to join the study and sign the informed consent.
Exclusion Criteria5
- Infected or had been infected with COVID-19;
- Active hepatitis B or C virus, HIV infection, or other uncured active infected persons;
- Patients with head and neck cancer who had received the following treatments:
- The patient had a history of using PD-1 and other immune checkpoint inhibitors 8 weeks before surgery; History of chemotherapy drug use 8 weeks before surgery; A history of hormone drug use within 4 weeks before surgery;
- Other situations that are not appropriate to be included in the clinical trial.
Interventions
OTHERNo intervention
This is a preclinical study. No intervention will be performed.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT05697926
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