RecruitingNot ApplicableNCT05699200

A Study to Analyze the Role of Sympathetic Nervous System in Spontaneous Coronary Artery Dissection

Role of the Neurovascular System in Spontaneous Coronary Artery Dissection (SCAD)

Sponsor

Mayo Clinic

Enrollment

50 participants

Start Date

Jun 1, 2023

Study Type

INTERVENTIONAL

Conditions

Healthy Spontaneous Coronary Artery Dissection

Summary

The purpose of this research is to compare sympathetic function (flight or fight system) and arterial health including structure and mechanics of participants with history of spontaneous coronary artery dissection (SCAD) to age and sex matched control participants.

Eligibility

Sex: FEMALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study investigates the role of the sympathetic nervous system — the body's "fight or flight" system — in spontaneous coronary artery dissection (SCAD), a rare and poorly understood heart condition in which one of the arteries supplying the heart tears spontaneously. SCAD primarily affects women and can cause heart attacks. Understanding its causes may lead to better treatments. You may be eligible if: - You are an adult female - Either you have a confirmed history of SCAD (verified by coronary angiography or CT angiography), OR you have no cardiac disease history and are being enrolled as a control participant You may NOT be eligible if: - You are pregnant - You have a known or suspected unstable cardiac condition within the last 4 weeks - You are currently receiving anticoagulation therapy or dual antiplatelet therapy - You are a prisoner Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERArterial Tonometry

We will measure arterial stiffness using arterial tonometry.

DIAGNOSTIC_TESTEchocardiogram

We will collect limited ultrasound images of the heart.

DIAGNOSTIC_TESTCarotid Ultrasounds

We will perform ultrasound imaging of the carotid artery.

DIAGNOSTIC_TESTElastography

We will measure the elastic properties of the arteries using elastography.

OTHERAnkle-Brachial Index

We will measure the ankle-brachial index to assess peripheral artery blood flow.

OTHERMicroneurography with sympathoexcitatory maneuvers

We will measure sympathetic nerve activity at rest and in response to isometric handgrip, mental stress test, cold pressor test, Valsalva maneuvers.

Locations(1)

Mayo Clinic Rochester

Rochester, Minnesota, United States

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NCT05699200

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