RecruitingNot ApplicableNCT05701280

Pilot/Pivotal Study of DBS+Rehab After Stroke

Rehab With Electrical Stimulation Therapy to Optimize Rehabilitation Effect (RESTORE): A Pivotal Study


Sponsor

Enspire DBS Therapy, Inc.

Enrollment

202 participants

Start Date

Feb 3, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

The RESTORE Stroke Study will evaluate the safety and effectiveness of DBS+Rehab for treating arm weakness and reduced function after a stroke.


Eligibility

Min Age: 21 Years

Inclusion Criteria1

  • Ischemic stroke, with an initial incident occurring between 12 months to 6 years before implant, resulting in residual upper extremity hemiparesis.

Exclusion Criteria2

  • Previous or subsequent cerebrovascular events resulting in residual upper extremity impairment
  • Brain lesions with significant involvement of the brainstem, cerebellum, or thalamus

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Interventions

DEVICEDeep Brain Stimulation

Deep Brain Stimulation (DBS) of the dentate nucleus area of the cerebellum plus motor rehabilitation to improve upper-extremity function.

OTHERRehabilitation

Motor rehabilitation to improve upper-extremity function.


Locations(10)

Barrow Neurological Institute (BNI)

Phoenix, Arizona, United States

Mayo Clinic Florida

Jacksonville, Florida, United States

Johns Hopkins School of Medicine

Baltimore, Maryland, United States

Massachusetts General Hospital

Boston, Massachusetts, United States

Mayo Clinic

Rochester, Minnesota, United States

NYU Langone Health

New York, New York, United States

Cleveland Clinic

Cleveland, Ohio, United States

Thomas Jefferson University

Philadelphia, Pennsylvania, United States

Rhode Island Hospital

Providence, Rhode Island, United States

Medical University of South Carolina (MUSC)

Charleston, South Carolina, United States

View Full Details on ClinicalTrials.gov

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NCT05701280


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