RecruitingPhase 1NCT05701527

A Study of EBC-129 in Advanced Solid Tumours

A Phase 1A/B Study To Evaluate The Safety And Tolerability Of EBC-129 As A Single Agent And In Combination With Pembrolizumab In Advanced Solid Tumours


Sponsor

EDDC (Experimental Drug Development Centre), A*STAR Research Entities

Enrollment

98 participants

Start Date

Apr 28, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

This study will assess the safety and tolerability of EBC-129 as a single agent and in combination with pembrolizumab in patients with advanced solid tumours


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called EBC-129 and a drug called Pembrolizumab for people with advanced solid tumours. The study is currently recruiting participants at 5 locations. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGEBC-129

EBC-129 will be administered on Day 1 of each 21-Day cycle (Parts A, B, and C), and two doses starting from Day 1 for 21-day cycle and three doses starting from Day 1 for 28-day cycle (Part D) via a 30-120-minute intravenous (IV) fusion.

DRUGPembrolizumab

Pembrolizumab will be administered at the dose of 200 mg IV every 21 days.


Locations(5)

University of Colorado Hospital (UCH) - University of Colorado Cancer Center (UCCC) - Neuroendocrine Tumor Center

Aurora, Colorado, United States

UT MD Anderson Cancer Center

Houston, Texas, United States

National University Hospital - Medical Oncology

Singapore, South West, Singapore

National Cancer Centre Singapore

Singapore, South West, Singapore

Taipei Veterans General Hospital

Taipei, Taipei, Taiwan

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

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NCT05701527


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