First in Human Study of SIM0610 in Solid Tumors

This is a first-in-human study testing a new cancer drug called SIM0610 for people with advanced solid tumors (cancer that has spread and cannot be cured with standard treatments). The study starts with finding a safe dose, then expands to specific cancer types including lung cancer, liver cancer, head and neck cancer, and colorectal cancer. **You may be eligible if...** - You are 18 or older with confirmed advanced or metastatic solid tumor cancer - Your cancer has progressed despite at least one prior standard treatment - You are in good physical condition (ECOG 0 or 1) - Your expected survival is at least 12 weeks - You can swallow tablets and have good organ function **You may NOT be eligible if...** - You have had another active cancer in the past 2 years - You have cancer in the brain causing symptoms or requiring treatment - You have had lung inflammation (ILD) requiring steroids - You have uncontrolled fluid buildup around the heart, lungs, or abdomen - You have had a recent heart attack, stroke, or severe heart failure - You have HIV, active infections requiring treatment, or had an organ transplant - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.