RecruitingPhase 4NCT05703919

Standard vs Targeted Oxygen Therapy Prehospital for Chronic Obstructive Pulmonary Disease

Sponsor

Central Denmark Region

Enrollment

1,888 participants

Start Date

Jun 2, 2025

Study Type

INTERVENTIONAL

Conditions

COPD Exacerbation COPD Exacerbation Acute

Summary

The STOP-COPD trial is a randomized, patient-blinded, prehospital clinical trial designed to evaluate the effect of titrated oxygen therapy compared to standard oxygen treatment in patients with suspected acute exacerbation of chronic obstructive pulmonary disease (AECOPD) treated with inhaled bronchodilators. The primary objective is to determine whether a titrated oxygen strategy targeting SpO₂ 88-92% can reduce 30-day mortality compared to the current standard practice using 100% compressed oxygen as a nebulizer driver.

Eligibility

Min Age: 40 Years

Plain Language Summary

Simplified for easier understanding

This trial compares giving a fixed high oxygen flow versus adjusting oxygen to a target level in people having a COPD flare-up treated by emergency medical services before reaching the hospital. **You may be eligible if...** - You are over 40 years old - You are suspected by emergency responders to be having a COPD flare-up - Your COPD is confirmed **You may NOT be eligible if...** - Your breathing problem is caused by asthma or an allergic reaction - You are pregnant - You are receiving non-invasive or invasive ventilation before the study treatment begins - You are allergic to inhaled bronchodilators (salbutamol) - You are being transferred between hospitals - You already received more than 2 doses of salbutamol before study treatment starts Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DRUGTitrated Oxygen

Titrated oxygen strategy - a mix of supplemental oxygen and compressed atmospheric air as driver for inhaled bronchodilators to target SpO2 88-92%

DRUGStandard Oxygen

Standard care using compressed oxygen (100%) as driver for inhaled bronchodilators

Locations(1)

Prehospital Emergency Medical Servises, Central Denmark Region

Aarhus N, Denmark

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT05703919

Related Trials

Evaluation of High Dose Prednisolone Pharmacokinetics in the Acute and Chronic Setting

NCT050120331 location

Predicting Adverse Outcomes Using Machine Learning of COPD Patients in Hong Kong

NCT058250141 location

Emotional-distress-based Integrated Care Programme in Patients With an Acute Exacerbation of COPD

NCT073519291 location

High-intensity Resistance Training in Post-exacerbation COPD

NCT073024251 location

DUET Versus Standard Interface for Hypercapnic COPD Patients

NCT058290832 locations