RecruitingNCT05705531

A Study About How Blood Cell Growth Patterns Relate to Heart Health After Treatment for Hodgkin Lymphoma

Assessment of Clonal Hematopoiesis and Its Relationship to Cardiovascular Disease in Hodgkin Lymphoma Survivors

Sponsor

Children's Oncology Group

Enrollment

190 participants

Start Date

Aug 18, 2023

Study Type

OBSERVATIONAL

Conditions

Classic Hodgkin Lymphoma Cardiovascular Disorder Clonal Hematopoiesis

Summary

This study assesses how blood cell growth patterns (clonal hematopoiesis) relate to heart health or cardiovascular disease (CVD) after treatment in patients with Hodgkin lymphoma. In some patients, cancer treatment at a young age may lead to later complications, including problems with heart health. Checking for blood cell growth patterns called therapy-related clonal hematopoiesis (t-CH) can help predict who might be at risk for heart health problems after Hodgkin lymphoma treatment. If doctors know who may be at greater risk for developing later heart complications, then they can more closely monitor those patients to prevent or detect heart complications early.

Eligibility

Min Age: 7 Years

Plain Language Summary

Simplified for easier understanding

This study is examining the relationship between clonal hematopoiesis — a condition where blood stem cells develop mutations over time — and heart health in childhood and adolescent survivors of Hodgkin lymphoma who received chemotherapy that can affect the heart. **You may be eligible if...** - You are 7 years of age or older - You were diagnosed with classical Hodgkin lymphoma between ages 2 and 22 - You received a cumulative anthracycline dose of 200 mg/m² or higher as part of your frontline treatment - All cancer treatment was completed at least 2 years ago - You have not had a cancer relapse or second cancer - You can undergo a cardiac MRI without sedation **You may NOT be eligible if...** - You have a medical reason that prevents cardiac MRI - You had the nodular lymphocyte-predominant subtype of Hodgkin lymphoma - You received additional cancer therapy beyond your original Hodgkin lymphoma treatment Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREArchive Sample Retrieval

Undergo collection of archived blood sample

PROCEDUREBiospecimen Collection

Undergo blood sample collection

OTHERElectronic Health Record Review

Undergo medical record abstraction

PROCEDUREMagnetic Resonance Imaging

Undergo MRI

OTHERSurvey Administration

Complete surveys

Locations(29)

USA Health Strada Patient Care Center

Mobile, Alabama, United States

Phoenix Childrens Hospital

Phoenix, Arizona, United States

Yale University

New Haven, Connecticut, United States

Alfred I duPont Hospital for Children

Wilmington, Delaware, United States

Golisano Children's Hospital of Southwest Florida

Fort Myers, Florida, United States

Arnold Palmer Hospital for Children

Orlando, Florida, United States

Saint Joseph's Hospital/Children's Hospital-Tampa

Tampa, Florida, United States

Children's Healthcare of Atlanta - Arthur M Blank Hospital

Atlanta, Georgia, United States

University of Maryland/Greenebaum Cancer Center

Baltimore, Maryland, United States

C S Mott Children's Hospital

Ann Arbor, Michigan, United States

Children's Hospitals and Clinics of Minnesota - Minneapolis

Minneapolis, Minnesota, United States

Washington University School of Medicine

St Louis, Missouri, United States

Hackensack University Medical Center

Hackensack, New Jersey, United States

Albany Medical Center

Albany, New York, United States

Roswell Park Cancer Institute

Buffalo, New York, United States

Wake Forest University Health Sciences

Winston-Salem, North Carolina, United States

Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, United States

Nationwide Children's Hospital

Columbus, Ohio, United States

Oregon Health and Science University

Portland, Oregon, United States

Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, United States

Children's Hospital of Pittsburgh of UPMC

Pittsburgh, Pennsylvania, United States

East Tennessee Childrens Hospital

Knoxville, Tennessee, United States

Cook Children's Medical Center

Fort Worth, Texas, United States

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center

Houston, Texas, United States

Children's Hospital of San Antonio

San Antonio, Texas, United States

University of Virginia Cancer Center

Charlottesville, Virginia, United States

Seattle Children's Hospital

Seattle, Washington, United States

University of Wisconsin Carbone Cancer Center - University Hospital

Madison, Wisconsin, United States

Hospital for Sick Children

Toronto, Ontario, Canada

View Full Details on ClinicalTrials.gov

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NCT05705531

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