RecruitingNCT05706194

Early Neuroprognostication After OHCA

Early Neurological Prognostication of Outcome After Out-of-hospital Cardiac arrest-a STEPCARE Prospective Substudy

Sponsor

Lund University

Enrollment

1,000 participants

Start Date

Oct 1, 2023

Study Type

OBSERVATIONAL

Conditions

Biomarkers Cardiac Arrest Brain Injuries CT EEG Neurological Outcome

Summary

This is a prospective observational substudy of the STEPCARE trial ClinicalTrials.gov Identifier: NCT05564754) with the aim to examine whether prognostication of neurological outcome after cardiac arrest can be performed earlier than the 72 h time-point recommended by guidelines today.

Eligibility

Min Age: 18 YearsMax Age: 100 Years

Inclusion Criteria4

a minimum of 20 minutes without chest compressions
Unconsciousness defined as not being able to obey verbal commands (FOUR-score motor response of \<4) or being intubated and sedated because of agitation after sustained ROSC
Eligible for intensive care without restrictions or limitations
Inclusion within 4 hours of ROSC

Exclusion Criteria5

On ECMO prior to randomisation
Pregnancy
Suspected or confirmed intracranial hemorrhage
Previously randomised in the STEPCARE trial
Patients with limitations in level-of-care due to for example generalized malignancy

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Interventions

DIAGNOSTIC_TESTEarly neurological prognostication with biomarkers, EEG and CT

Biomarker samples collected at 12, 24, 48 and 72 h after randomisation, CT and EEG performed as early as possible after 24 h post randomisation in patients still unconscious (defined as not awake and able to follow verbal commands)