The Effectiveness of Adding Braun Anastomosis to Standard Child Reconstruction After Pancreatoduodenectomy
The Effectiveness of Adding Braun Anastomosis to Standard Child Reconstruction to Reduce Delayed Gastric Emptying After Pancreatoduodenectomy (REMBRANDT): a Multicenter Randomized-controlled Trial
Radboud University Medical Center
256 participants
Apr 17, 2023
INTERVENTIONAL
Conditions
Summary
The goal of this clinical trial (REMBRANDT) is to evaluate the effectiveness of adding an extra connection (i.e. 'Braun anastomosis') after standard reconstruction in pancreatic head resection in reducing the incidence of delayed gastric emptying.
Eligibility
Inclusion Criteria3
- Undergoing open pancreatoduodenectomy
- Provided informed consent
- Age over 18 years
Exclusion Criteria6
- Insufficient control of the Dutch language to read the patient information and to fill out the questionnaires in Dutch hospitals
- Previous bariatric surgery (such as Roux-en-Y gastric bypass, gastric sleeve)
- Pregnancy
- Bowel motility disorders
- Minimally invasive pancreatoduodenectomy
- Gastric outlet syndrome
Interventions
Participants will undergo open pancreatoduodenectomy (PD). The reconstruction technique will not be standardized. In addition to the reconstruction technique used, a side-to-side anastomosis will be created between the afferent and efferent jejunal limbs of the gastrojejunostomy (GJ) at 20 cm distance from the GJ. The anastomosis will be hand-sewn with monofilament PDS 3-0 one-layer running suture.
Participants will undergo open pancreatoduodenectomy (PD). The reconstruction technique will not be standardized. The surgeon is able to perform the PD as normally would be done (antecolic, retrocolic, pylorus-preserving or with distal gastric resecting).
Locations(12)
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NCT05709197