Evaluating the Utility of RELiZORB™ for Treating Feeding Intolerance in Critically Ill Adults With Multi-Organ Failure

This study tests a device called RELiZORB — an enzyme cartridge attached to feeding tubes — in critically ill adults with multi-organ failure (MOF). Many ICU patients cannot digest fats well due to their critical illness, leading to poor nutrition even when tube feeding is provided. RELiZORB breaks down fats in the feeding formula before they reach the gut, which may improve calorie absorption and nutritional outcomes for very ill patients. You may be eligible if: - You are between 18 and 89 years old - You are in the ICU with multi-organ failure (requiring mechanical ventilation plus at least one other organ failure) - You have not yet started tube feeding or started within the past 48 hours - If you cannot consent yourself, a legally authorized representative may consent on your behalf You may NOT be eligible if: - You are pregnant or a prisoner - You have low blood pressure due to suspected cardiogenic shock - You have an intestinal obstruction, ischemia, bleeding, perforation, fistula, or other contraindication to tube feeding - Your sepsis is suspected to originate from an abdominal source and tube feeding is contraindicated - You have a C. diff or other gastrointestinal infection with diarrhea - You are taking pancreatic enzyme supplements or hormones (e.g., octreotide) - The treating team has another reason to avoid tube feeding Talk to your doctor to see if this trial is right for you.