RecruitingNot ApplicableNCT05710549

Understanding Brain Mechanisms Involved in Autobiographical Memory

Understanding Brain Mechanisms Involved in Autobiographical Memory Using High-density Electroencephalography and Transcranial Alternating Current Stimulation


Sponsor

Lucie Bréchet

Enrollment

120 participants

Start Date

Apr 25, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

The overall objective of this project is to characterize the spatiotemporal dynamics of brain oscillations underpinning autobiographical memory (ABM) and the modulation of the memory network using non-invasive brain stimulation.


Eligibility

Min Age: 18 YearsMax Age: 85 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating the brain mechanisms involved in autobiographical memory — the ability to recall personal life experiences — comparing younger adults, older adults without cognitive problems, and people with mild cognitive impairment (early-stage memory problems). **You may be eligible if...** - You are a younger adult (18–35) or older adult (55+) without cognitive impairment, OR - You are 55 or older with a clinical diagnosis of mild cognitive impairment (MCI) - MCI participants must have a cognitive test score of 18 or above and a stable medication dose for at least 6 weeks - You completed at least 8th grade education (MCI group) - You are willing and able to participate in MRI scanning **You may NOT be eligible if...** - You have major depression, schizophrenia, or psychosis - You are blind or have other disabilities preventing task completion - You have metal implants in your body that are not MRI-safe - You are under 55 with a cognitive impairment diagnosis Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEhigh-density electroencephalography (hdEEG)

EEG will be recorded with a 257-channel EEG system (Geodesic Sensor Net, MegStim). An EEG net is applied at once on the head with evenly spaced sensors that provide full scalp coverage, including the cheek, Ag/Ag-Cl electrodes that are interconnected by thin rubber bands and contain small sponges soaked with saline water that touches the participant's scalp surface directly. Net application takes about 10 min to derive impedances to \<30 kOhms. EEG is recorded with 1 kHz and band-pass filtered between 0.1-200 Hz. Vertex electrode Cz is used as an acquisition reference.

DEVICETranscranial alternating current stimulation (tACS)

tACS will be delivered by a battery-driven current stimulator Starstim SS32 (Neuroelectrics) through surface Ag/AgCl electrodes placed into holes of a neoprene cap corresponding to the international 10/20 EEG system. Gel (Parker Lab, Inc.) will be applied to optimize signal conductivity and lower impedance.


Locations(1)

University of Geneva, Campus Biotech

Geneva, Canton of Geneva, Switzerland

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NCT05710549


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