REALITY MONITORING
MONITORING OF REALITY AND DOPAMINE: A PHARMACOLOGICAL RESEARCH
Hôpital le Vinatier
39 participants
Jan 15, 2024
INTERVENTIONAL
Conditions
Summary
Reality-monitoring characterizes the ability to determine whether information was perceived in the environment or only imagined . Impaired reality-monitoring abilities have been associated with hallucinations in patients with schizophrenia and patients with Parkinson's disease. The investigators hypothesize a link between dopaminergic (DA) transmission and reality-monitoring.
Eligibility
Inclusion Criteria5
- Healthy volunteers who have given their written informed consent
- Men and women from 18 to 45 years old
- Normal or corrected vision
- Being fluent in French or French for native language
- Being affiliated with health insurance
Exclusion Criteria22
- Healthy volunteers who have given their written informed consent
- Men and women from 18 to 45 years old
- Normal or corrected vision
- Being fluent in French or French for native language
- Being affiliated with health insurance
- Inadmissibility of the subject's consent or refusal
- Working-memory deficit (as controlled with MMSE score< 23)
- Any past or current psychiatric or somatic condition(as controlled with the Mini International Neuropsychiatric Interview, MINI)
- Any past or current neurological condition
- History of cranio-cerebral trauma, arterial hypotension or hypertension, cardiological or serious medical condition
- Abnormal potassium dosage (below 3.1 mmol/L or above 4.9 mmol/L)
- Anormal ECG
- History of schizophrenia or bipolar disorder in first-degree relatives
- Alcohol-drinking and caffeine intake at least during 24 hours before each session
- Drug therapy excepting contraceptives
- Cardiologic or severe medical conditio
- Pregnancy(checked with a pregnancy autotest), lactation, or insufficient contraceptive measure (precautionary measure)
- Consumption of recreational drugs during the last 6 months
- Known sensitivity to any of the study medication and their excipients
- Lactose intolerance
- Porphyria
- Hepatic insufficiency
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Interventions
In the first condition, volunteers will receive a 100mg dose of L-dopa, 25mg dose of Aromatic amino acid decarboxylase inhibitors (Benserazide) and 10mg dose of Domperidone. In the second condition, volunteers will receive Sulpiride 800mg. In the third condition, volunteers will receive placebo Reality-monitoring performances will be evaluated with a standardized task. Working-memory will be evaluated with the n-back task. Self-monitoring performances will be observed during a speech production experiment in which speakers monitor their auditory feedback while speaking. Speech Bayesian reasoning: This task is a home-made task investigating the influence of prior on speech processing. Subjects will be required to identify speech in ambiguous auditory stimuli. Visual Bayesian reasoning: This task investigates the influence of prior on visual processing. Subjects will be required to recognize morph between faces and house.
In the second condition, volunteers will receive Sulpiride 800 mg
In the third condition, volunteers will receive placebo
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT05711082