RecruitingNCT05712733

Cholecystitis From a Microbiological and Histopathological Perspective

Sponsor

Organkirurgisk afdeling, sygehus lillebælt, Kolding

Enrollment

60 participants

Start Date

Apr 1, 2023

Study Type

OBSERVATIONAL

Conditions

Antibiotic Resistant Infection Calculous Cholecystitis

Summary

The aim of this project is to investigate the presence of bacteria in the gallbladder wall and the bile in patients undergoing cholecystectomy, to determine if the standard empirical antibiotic treatment used currently is effective against the most common pathogens.

Eligibility

Min Age: 18 Years

Inclusion Criteria3

Age above 18 years
Signed consent form
Patients having cholecystectomy performed at the Department of Surgery, Sygehus Lillebælt, Kolding.

Exclusion Criteria4

Administration of any type of antibiotics one month prior to surgery in the control group.
Previous instrumentation of the bileducts
Previous clinical acute cholecystitis treated conservatively with antibiotics
Patients will be precluded from the studypopulation in cases of pPerioperative perforation of the gallbladder, or conversion to open cholecystectomy or in cases of failed attempts to extract bile or samples from the gallbladder wall.

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Interventions

OTHERMicrobiological and histopathological investigation of bile and gallbladder wall specimens.

Bile and gallbladder wall specimens will be taken from all patients included in the study. The material will be sent for microbiological and histopathological investigation.