RecruitingPhase 3NCT05717803

Segmentectomy for Ground Glass-dominant Invasive Lung Cancer (ECTOP-1012)

Segmentectomy for Ground Glass-dominant Invasive Lung Cancer With Size of 2-3cm: a Single-arm, Multi-center, Phase III Trial

Sponsor

Fudan University

Enrollment

307 participants

Start Date

Feb 15, 2023

Study Type

INTERVENTIONAL

Conditions

Lung Adenocarcinoma Segmentectomy

Summary

This is a clinical trial from Eastern Cooperative Thoracic Oncology Project (ECTOP), numbered as ECTOP-1012. The goal of this clinical trial is to confirm the theraputic effect of segmentectomy for ground glass-dominant invasive lung cancer with size of 2-3cm. The main questions it aims to answer are: * The 5-year disease-free survival of patients having ground glass-dominant invasive lung cancer with size of 2-3cm; * The post-operative lung function tests after receiving segmentectomy. Participants will receive segmentectomy as the surgical procedure.

Eligibility

Min Age: 18 YearsMax Age: 80 Years

Inclusion Criteria10

Patients who sign the informed consent form and are willing to complete the study according to the plan;
Aged from 18 to 80 years old;
ECOG equals 0 or 1;
Not receiving lung cancer surgery before;
Confirmed to be invasive lung adenocarcinoma intraoperatively or postoperatively;
Ground glass-dominant lung nodules
Consolidation-to-tumor ratio (CTR) ranges from 0 to 0.5, and tumor size ranges from 2 to 3cm;
cN0 without distant metastasis;
Tumors could be completely resected assed by surgeons;
Not receiving chemotherapy or radiotherapy before.

Exclusion Criteria5

CTR is not 0-0.5, or size is not 2-3cm;
Tumors could not be completely resected assed by surgeons;
Not lung adenocarcinoma diagnosed cytologically or pathologically;
Receiving lung cancer surgery before;
Receiving radiotherapy or chemotherapy.

Interventions

PROCEDURESegmentectomy

The lungs are divided into multiple lobes. A segmentectomy involves the removal of part of one of the lobes of the lung to entirely remove a cancerous tumor. segmentectomy can preserve more normal functional lung tissues.