RecruitingNot ApplicableNCT05718245

HEPA, PM2.5, and Cardiometabolic Health

Using Indoor Air Filtration to Reduce PM2.5 Cardiometabolic Effects in At-risk Individuals

Sponsor

University of Southern California

Enrollment

52 participants

Start Date

Mar 15, 2023

Study Type

INTERVENTIONAL

Conditions

Air Pollution

Summary

The goal of this randomized, double-blind, crossover trial is to test the hypothesis that a longer-term indoor HEPA filtration intervention can improve cardiometabolic profiles by reducing indoor PM2.5 exposures in at-risk individuals.

Eligibility

Min Age: 65 YearsMax Age: 84 Years

Inclusion Criteria5

Age between 65 and 84 years old;
Nonsmoker for at least 1 year;
History of BMI ≥ 25 kg/m2 in the past based on EMR information;
Either an English or Spanish speaker;
Live in the Los Angeles County.

Exclusion Criteria8

History of diabetes (both type 1 and type 2) or degenerative disease of the nervous system (Alzheimer's disease or dementia);
Currently have active cancer treatment;
The residential house has already had HEPA filters;
Participants will move out of the current house in the next 2 years;
Participants will spend more than one month living outside the primary home;
Have any health conditions that prohibit collecting health and covariate data and biospecimen;
The residential houses are not feasible for setting up air purifiers and air pollutants monitors;
Have high blood glucose from finger stick test (\> 200 mg/dL).

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