The Role of Macrophage Activation in Lung Injury Following Ozone Exposure
Activated Macrophages and Ozone Toxicity II
Rutgers, The State University of New Jersey
120 participants
Feb 7, 2023
INTERVENTIONAL
Conditions
Summary
The purpose of the study is to better understand the mechanisms of lung injury from ozone exposure. Subjects will participate in two exposure sessions: filtered air and 0.2 ppm ozone. The exposure visits will be at least 2 weeks apart. Subjects will be asked to produce sputum through coughing after each exposure. The samples will be analyzed for macrophage activity.
Eligibility
Exclusion Criteria10
- Cardiovascular disease
- Respiratory disease
- Recent (within 4 weeks) respiratory or COVID-19 symptoms
- Diabetes
- Pregnancy
- HIV Infection
- History of smoking within the past 5 years.
- Orthopedic or rheumatologic conditions which would interfere with cycle use
- Inability to produce a sputum plug at screening
- Daily use of antioxidant supplements, excluding those in a multivitamin. These supplements include Vitamin C or E, selenium, beta-carotene, lycopene, lutein, zeaxanthin and ginkgo biloba. Supplements taken less frequently but at least once a week will be reviewed by the principal investigator for eligibility determination.
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Interventions
Subjects will be exposed to clean air for 3 hours.
Subjects will be exposed to 0.2 ppm ozone for 3 hours.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT05794087