RecruitingNot ApplicableNCT05721781

Reducing Risk for Infective Endocarditis

Reducing Risk for Infective Endocarditis (IE): A Randomized Trial of a Professional Scaling and Oral Hygiene Instruction Intervention to Reduce Tooth Brushing-Associated Bacteremia


Sponsor

Wake Forest University Health Sciences

Enrollment

320 participants

Start Date

Aug 31, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

This clinical trial is studying if bacteria found in a participant's bloodstream after brushing their teeth can be prevented with a dental cleaning and more education on how to best brush and care for their teeth. One group of participants will have a dental cleaning and oral health instructions and the other group of participants will not. Researchers will compare the blood test results from the two groups to see if the education made a difference in preventing bacteria and how long it stays in the bloodstream.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a procedure called Dental Cleaning and a behavioral approach called Oral Hygiene instruction for people with bacteremia and infective endocarditis. The study is currently recruiting participants at 6 locations. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALOral Hygiene instruction

Participants will be instructed on the Modified Bass technique for toothbrushing: brushing with a soft bristled toothbrush held at a 45 degree angle to the gums and brushed in a circular motion. Participants will also be instructed to floss at least once per day using floss or another inter-dental device (e.g., floss pick).

PROCEDUREDental Cleaning

Participants will receive a dental cleaning according to the current standard of care for routine dental cleanings.


Locations(6)

Tufts University School of Dental Medicine and Tufts University Health Sciences Campus

Boston, Massachusetts, United States

University of Michigan School of Dentistry and Michigan Medicine

Ann Arbor, Michigan, United States

Rutgers School of Dental Medicine

Newark, New Jersey, United States

New York University

New York, New York, United States

University of Rochester Medical Center

Rochester, New York, United States

Atrium Health's Carolinas Medical Center

Charlotte, North Carolina, United States

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NCT05721781


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