RecruitingNCT05728996

Netherlands Cohort Study on Acute HIV Infection

Sponsor

Prof. Jan Prins

Enrollment

183 participants

Start Date

Aug 1, 2015

Study Type

OBSERVATIONAL

Conditions

Acute HIV Infection

Summary

Investigation of the size, variability and localization of the (pro) viral reservoir and the properties of HIV-specific immune response related to "post-treatment viral remission' achievement and / or duration. In addition we will study the factors that determine latency in the different host cells, their sensitivity to induction of replication competent virus by various agents and the potential application of these agents in "post-treatment viral remission". This all will be studied in patients included during acute phase of the infection who start antiretroviral therapy immediately upon diagnosis.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study in the Netherlands is following people who have been very recently diagnosed with HIV (acute HIV infection) to understand how the body's immune system responds in the earliest stages of infection. This research could help develop better vaccines and treatments. **You may be eligible if...** - You are 18 or older - You have a confirmed acute (very early) HIV-1 infection (Fiebig stages I–IV) - You are willing to provide blood samples and consent to optional procedures like tissue sampling **You may NOT be eligible if...** - You have had HIV for a longer period (chronic infection) - You are unwilling to provide samples for genetic testing - You are unable to give written informed consent Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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