RecruitingNCT05728996

Netherlands Cohort Study on Acute HIV Infection

Sponsor

Prof. Jan Prins

Enrollment

183 participants

Start Date

Aug 1, 2015

Study Type

OBSERVATIONAL

Conditions

Acute HIV Infection

Summary

Investigation of the size, variability and localization of the (pro) viral reservoir and the properties of HIV-specific immune response related to "post-treatment viral remission' achievement and / or duration. In addition we will study the factors that determine latency in the different host cells, their sensitivity to induction of replication competent virus by various agents and the potential application of these agents in "post-treatment viral remission". This all will be studied in patients included during acute phase of the infection who start antiretroviral therapy immediately upon diagnosis.

Eligibility

Min Age: 18 Years

Inclusion Criteria5

Written informed consent to store samples and perform genetic testing.
Separate written informed consent for invasive sampling procedures: leukapheresis, sigmoidoscopy with biopsies, lymph node excision biopsy and lumbar puncture, with storage of samples.
Age \>= 18 years
An acute HIV-1 infection, defined according to the Fiebig stages I-IV (acute infection), as described in the previous paragraph (HIV-1 RNA positive and 4th generation ELISA negative or HIV-1 RNA positive and 4th generation HIV ELISA positive with indeterminate Western Blot). Patients in Fiebig stage V and VI (recent infection) will only be included if they have a documented negative HIV test 6 months prior to the positive test or if they are in Fiebig stage V with a p31 negative blot
Female subjects should be willing to use adequate contraception.

Exclusion Criteria3

Contraindication for proposed cART regimen (e.g. impaired renal function).
Mental disorder that in the view of the investigator would interfere with adherence to the treatment or the study procedures, or the decision to participate in the study.
Immunosuppressive medication or other diseases associated with immunodeficiency.