RecruitingPhase 2NCT05730816

MAGIC AKI: Magnesium for the Prevention of HIOC-Associated AKI

MAGIC-AKI: Magnesium for the Prevention of Hyperthermic Intraoperative Cisplatin-Associated AKI

Sponsor

Brigham and Women's Hospital

Enrollment

130 participants

Start Date

Apr 4, 2023

Study Type

INTERVENTIONAL

Conditions

Mesothelioma

Summary

In this research study, investigators will test whether prophylactic high-dose IV Mg administration attenuates the risk of AKI in patients with malignant mesothelioma receiving intraoperative chemotherapy (HIOC) with cisplatin compared to placebo .

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether giving magnesium supplements can prevent kidney injury in people with malignant mesothelioma (a rare cancer linked to asbestos) who are undergoing a specialized heated chemotherapy procedure inside the chest cavity during surgery (called HIOC). **You may be eligible if...** - You are 18 or older - You have malignant mesothelioma - You are scheduled for surgery that includes the HIOC procedure at Brigham and Women's Hospital - Your kidney function is adequate (eGFR of 45 or higher) **You may NOT be eligible if...** - You have reduced kidney function (eGFR below 45) - You are already on dialysis or have end-stage kidney disease - You are not having HIOC as part of your surgery Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGMagnesium sulfate

Intravenous infusion of magnesium sulfate prior to intraoperative chemotherapy with cisplatin.

DRUGNormal Saline

Intravenous infusion of normal saline.

Locations(1)

Brigham and Women's Hospital

Boston, Massachusetts, United States

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NCT05730816

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