Nicotinamide Riboside and Prevention of Cancer Therapy Related Cardiac Dysfunction in Breast Cancer Patients

This study looks at whether a supplement called nicotinamide riboside (a form of vitamin B3, sold as Niagen) can protect the heart in women with advanced breast cancer who are receiving chemotherapy drugs called anthracyclines. These chemotherapy drugs are effective against cancer but can sometimes damage the heart. Researchers want to see if this supplement can reduce or prevent that damage. **You may be eligible if...** - You are a woman with stage IV (metastatic) breast cancer - You are scheduled to receive anthracycline-based chemotherapy - You are 18 years or older - You are in reasonably good overall health **You may NOT be eligible if...** - You had a heart attack in the last 3 months - You have a life expectancy of less than 6 months - You are allergic to any ingredient in the nicotinamide riboside (Niagen) tablet - You have a condition that would prevent you from having a cardiac MRI scan - You are currently participating in another drug trial or took an experimental drug recently - You have a psychiatric disorder, alcohol or substance misuse, or other condition that would prevent you from following the study Talk to your doctor to see if this trial is right for you.