MT2021-08T Cell Receptor Alpha/Beta Depletion PBSC Transplantation for Heme Malignancies

This trial tests a type of stem cell transplant (using donor cells from blood) with a specific purification method called T-cell receptor alpha/beta depletion. This technique removes certain immune cells that can attack the patient's own body after transplant (called graft-versus-host disease), while preserving cells that fight the cancer. The study is for people with blood cancers (such as leukaemia or MDS) who need a bone marrow transplant from a donor. **You may be eligible if...** - You have been diagnosed with a blood cancer such as AML, ALL, or MDS - Your cancer is at a stage where a stem cell transplant is recommended - You are 60 years old or younger - You are in reasonably good health (Karnofsky or Lansky performance score ≥ 70%) - Your vital organ function is adequate **You may NOT be eligible if...** - You are pregnant or breastfeeding - You have an active, uncontrolled infection - You are HIV positive, or have active hepatitis B or C (detectable virus) - You have previously had a bone marrow or stem cell transplant - You have leukaemia that has spread to the brain or spinal cord - You have CML in blast crisis Talk to your doctor to see if this trial is right for you.