Construction of Molecular Diagnostic Marker Model for Pancreatic Cystic Tumors Based on Pancreatic Cystic Fluid Samples
Construction of Molecular Diagnostic Marker Models for Pancreatic Cystic Tumors Based on CfDNA Methylation Sequencing and Proteomic Analysis of Pancreatic Cystic Fluid Samples
Zhaoshen Li
100 participants
Mar 1, 2023
OBSERVATIONAL
Conditions
Summary
The goal of this observational study is to test in patients with cystic tumor of pancreas. The main questions it aims to answer are: Screening of molecular diagnostic markers for pancreatic cystic tumors by cfDNA methylation sequencing of pancreatic cystic fluid and proteomic assays to distinguish benign from malignant and mucinous/non-mucinous, correlate with pathological features, and find molecular features associated with the degree of malignancy. Participants will Provide post-operative cyst fluid specimens.
Eligibility
Inclusion Criteria4
- Subjects are ≥ 18 years old, regardless of gender;
- Preoperative imaging examination (EUS, CT, MRI) diagnosed cystic mass of pancreas and suspected cystic tumor;
- Subjects voluntarily accepted radical resection of pancreatic cystic tumors;
- Subjects or family members voluntarily sign the informed consent form for clinical research.
Exclusion Criteria5
- The excised sample does not contain cystic components, or the cystic fluid cannot be collected;
- Receive tumor-related treatment (radiotherapy, chemotherapy, immunotherapy, etc.) before operation;
- Receive antibiotic treatment within 1 week before operation;
- Subjects refused to accept radical resection of pancreatic cystic tumor, or had any situation that they could not accept radical resection of pancreatic cystic tumor;
- The subjects or their families refused to sign the informed consent form for clinical research.
Interventions
Sequencing of cfDNA methylation and proteomic analysis of two sets of capsular fluid samples
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT05737953