High-dose Accelerated Theta Burst Stimulation for the Treatment of Alcohol Addiction
Theta Burst Zur Behandlung Der Alkoholabhängigkeit
Berthold Langguth, MD, Ph.D.
72 participants
Mar 1, 2023
INTERVENTIONAL
Conditions
Summary
This is a two-arm randomized placebo-controlled trial in which 72 patients with alcohol addiction are treated with high-dose accelerated intermittent theta burst stimulation (TBS).
Eligibility
Inclusion Criteria6
- alchohol dependence according to ICD-10 (F10.2)
- desire to reduce or abstain from alcohol drinking
- male or female
- -65 years
- residency in Germany, German speaking
- written informed consent
Exclusion Criteria11
- contraindications for transcranial magnetic stimulation (electric devices or metal parts in the body such as pacemaker)
- relevant neurological or internistic diseases according to study investigator
- treatment with TMS in the past
- participation in other trials during treatment
- pregnancy or breatfeeding
- positive breath test for alcohol
- legal care and placement in a psychiatric hospital
- co-medication with disulfiram, acamprosate, topiramate, baclofen, naltrexone, or nalmefene
- acute psychiatric comorbidity that requires inpatient treatment or medication readjustment (<1 month)
- severe chronic psychiatric illness (schizophrenia, schizoaffective disorder, bipolar disorder)
- patients who are unable to complete study questionnaires or follow-up questionnaires (in the opinion of the investigators)
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
1200 pulses of iTBS per session with five sessions per day applied at five days (Monday-Friday) with 120% resting motor threshold
1200 pulses of iTBS per session with five sessions per day applied at five days (Monday-Friday) with 120% resting motor threshold with angled coil
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT05738174