A Study of Endoscopic Sleeve Gastroplasty for Obesity in Ulcerative Colitis

This study is testing whether a non-surgical weight loss procedure called endoscopic sleeve gastroplasty (ESG) — where a doctor uses an endoscope (a flexible tube through the mouth) to stitch the stomach into a smaller sleeve shape — is safe and effective for people with obesity who also have ulcerative colitis (UC) and are planning certain bowel surgery. **You may be eligible if...** - Your BMI is between 30 and 50 kg/m² for at least 6 months - You have been diagnosed with ulcerative colitis and are planning or have already had a colectomy (colon removal) as part of a multi-stage bowel reconstruction - You are willing to follow the required diet and behavior changes - If female, you are not pregnant and are using contraception or are post-menopausal **You may NOT be eligible if...** - You have previously had bariatric (weight loss) surgery or other stomach surgery - You have a gastric or duodenal ulcer, esophageal varices, or large hiatal hernia with severe reflux - You have serious clotting problems, liver failure, or cirrhosis - You have uncontrolled psychiatric illness Talk to your doctor to see if this trial is right for you.