RecruitingNot ApplicableNCT05739617

Comprehensive Respiratory Training Exercise Program in Obstructive Sleep Apnea

Combining Sonography to Explore the Therapeutic Effect and Mechanism of a Comprehensive Respiratory Training Exercise Program on Cardiorespiratory Endurance and Airway Muscle Function in Obstructive Sleep Apnea


Sponsor

National Cheng-Kung University Hospital

Enrollment

150 participants

Start Date

Mar 1, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

Obstructive sleep apnea (OSA) is a multi-factorial sleep disorder. Complete collapse or partial collapse in the airway increases the risk of developing cardiovascular and kidney-related disease in OSA patients. Resulting in an increase in medical expenses and workload for the healthcare worker. Multilevel of upper airway muscles especially the genioglossus muscle showed to contribute to airway obstruction as it fatigues easily. The endurance level of OSA patients was shown to be significantly lower. Therefore, the goal of this experimental study is to assess the feasibility and effectiveness of a comprehensive respiratory training exercise program on cardiorespiratory endurance, airway muscle function, and sleep parameters in patients with obstructive sleep apnea (OSA). Aside from exploring the therapeutic effect, the results of the study will be used to explore the mechanism of the treatment in relation to the changes in the OSA severity.


Eligibility

Min Age: 20 YearsMax Age: 65 Years

Inclusion Criteria3

  • Newly diagnosed with OSA (AHI≥ 5 events per hour)
  • Age between 20 to 65 years old
  • BMI of 18-30 kg.m-2

Exclusion Criteria8

  • Central or mixed types of sleep apnea
  • Neuromuscular disease
  • Severe cardiovascular disease
  • Active psychiatric disease
  • Head or neck disease or cancer
  • Structural abnormalities over the upper respiratory airway
  • Performed any operation or treatment over the neck before
  • Pregnancy

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Interventions

OTHERComprehensive Respiratory Training Exercise Program

This comprehensive respiratory training exercise program consists of four main components, including oropharyngeal muscle training, respiratory muscle training, aerobic exercise, and sleep hygiene education.

OTHERSleep hygiene education

Sleep hygiene education


Locations(1)

National Cheng Kung University Hospital

Tainan, Taiwan, Taiwan

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NCT05739617


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