RecruitingNot ApplicableNCT05740163

Oral Immunotherapy for Egg Allergy in Children Aged 6 to 16

Sponsor

Tampere University Hospital

Enrollment

60 participants

Start Date

Dec 30, 2019

Study Type

INTERVENTIONAL

Conditions

Egg allergy

Summary

The aim of the study is to determine the efficacy of a 12-month egg oral immunotherapy (OIT) protocol with a cooked whole egg product including yolk and egg white. Study hypothesis: With this method the risk for severe allergic reaction to egg protein is reduced and the diet can partly or completely be normalized.

Eligibility

Min Age: 6 YearsMax Age: 16 Years

Inclusion Criteria4

Age 6 to 16 years
Elevated spesific serum IgE to egg (> 5 kU/l) and/or positive skin prick to egg allergen
Positive oral food challenge for egg or anaphylaxis reaction to egg within the 6 months
Diet free from egg in any form

Exclusion Criteria9

Age less than 6 years or more than 16 years
Poor asthma control or uncontrolled asthma
Severe/significant cardiovascular disease
Autoimmune disease
Malignancy
Medication: beta bloker, angiotensin-converting-enzyme inhibitors (ACE inhibitors), Monoamine oxidase inhibitors (MAOIs)
Poor compliance
Fear of immunotherapy
Desensitization to alfa-gal-protein (mammalian meat allergy)