RecruitingPhase 4NCT05745987

Smallpox Vaccine for Mpox Post-Exposure Prophylaxis: A Cluster RCT

SMART (Smallpox Vaccine for Mpox Post-Exposure Prophylaxis: A Cluster Randomized Controlled Trial)

Sponsor

McMaster University

Enrollment

3,000 participants

Start Date

Sep 17, 2024

Study Type

INTERVENTIONAL

Conditions

Monkeypox

Summary

A cluster randomized controlled trial to determine if smallpox vaccine reduces secondary cases and symptom severity in persons exposed to mpox.

Eligibility

Min Age: 2 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Bavarian Nordic smallpox vaccine and a drug called Typhoid VI Polysaccharide Vaccine Injectable Solution for people with monkeypox. The study is currently recruiting participants at 10 locations. People eligible for this study include aged 2 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGBavarian Nordic smallpox vaccine

A single dose of the Bavarian Nordic smallpox vaccine will be given at baseline.

DRUGTyphoid VI Polysaccharide Vaccine Injectable Solution

A single dose of the typhoid vaccine will be given at baseline.

Locations(10)

Catholic University of Bukavu

Kinshasa, Bukavu, Democratic Republic of the Congo

Federal Medical Center

Abuja, Nigeria

University of Abuja Teaching Hospital

Abuja, Nigeria

University of Ibadan

Ibadan, Nigeria

Irrua Specialist Teaching Hospital

Irrua, Nigeria

Aminu Kano Teaching Hospital

Kano, Nigeria

Lagos University Teaching Hospital

Lagos, Nigeria

Niger Delta Teaching Hospital

Okolobiri, Nigeria

University of Port Harcourt Teaching Hospital

Port Harcourt, Nigeria

Makerere University Lung Institute

Kampala, Uganda

View Full Details on ClinicalTrials.gov

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NCT05745987

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