RecruitingNCT05748028

Pain and Autonomic Symptoms in Parkinson's Disease and Atypical Parkinsonisms

Pain and Autonomic Symptoms in Parkinson's Disease and Atypical Parkinsonisms: Identification of Predictive Patterns of Rehabilitation Outcome and Evaluation of the Impact on Quality of Life

Sponsor

Istituti Clinici Scientifici Maugeri SpA

Enrollment

280 participants

Start Date

Jun 15, 2019

Study Type

OBSERVATIONAL

Conditions

Multiple System Atrophy Parkinson Disease

Summary

The goal of this observational study is to learn about the impact of the different types of pain and of the domains involved in the autonomic disorders of inpatients and outpatients diagnosed with Parkinson disease (PD) and multiple system atrophy (MSA) admitted to Istituti Clinici Scientifici Maugeri Centers. The main aims are: Evaluate the prevalence of pain and characterize it in Parkinson's disease and atypical parkinsonisms (MSA) Evaluate the effect of rehabilitation on pain and autonomic symptoms Evaluate the prevalence of autonomic symptoms in Parkinson's disease and atypical parkinsonisms (MSA) Assess the impact of pain and autonomic symptoms on quality of life. Participants will perform neurological examination, rehabilitation program and clinical scales. Researchers will compare the two groups of patients (PD and MSA) and the effect of the rehabilitation on pain, autonomic symptoms and quality of life.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating pain and autonomic symptoms (such as blood pressure changes, digestive issues, and sweating) in people with Parkinson's disease or atypical parkinsonism (conditions similar to Parkinson's), to better characterize and manage these often overlooked aspects of the disease. **You may be eligible if...** - You have a clinical diagnosis of Parkinson's disease or Multiple System Atrophy (MSA) according to current international standards - You are able to complete a basic cognitive test (Mini-Mental State Examination score of at least 10) **You may NOT be eligible if...** - Your parkinsonism was caused by medication or a stroke (vascular parkinsonism) - You have diabetes, significant liver or kidney disease, or thyroid disorders - You are taking medications known to be toxic to nerves Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERRehabilitation

All patients included in the study will undergo a basic evaluation with a neurological examination, a rehabilitation program to improve strength, coordination, balance, endurance, and the ability to perform activities of daily life.

OTHERAdministration of Clinical scales

All patients included in the study will be evaluated by clinical scales assessing the disease stage, clinical severity, freezing, motor and non-motor impairment, cognitive impairment, depression, quality of life, autonomic dysfunction, pain.