RecruitingNCT05748028

Pain and Autonomic Symptoms in Parkinson's Disease and Atypical Parkinsonisms

Pain and Autonomic Symptoms in Parkinson's Disease and Atypical Parkinsonisms: Identification of Predictive Patterns of Rehabilitation Outcome and Evaluation of the Impact on Quality of Life

Sponsor

Istituti Clinici Scientifici Maugeri SpA

Enrollment

280 participants

Start Date

Jun 15, 2019

Study Type

OBSERVATIONAL

Conditions

Multiple System Atrophy Parkinson Disease

Summary

The goal of this observational study is to learn about the impact of the different types of pain and of the domains involved in the autonomic disorders of inpatients and outpatients diagnosed with Parkinson disease (PD) and multiple system atrophy (MSA) admitted to Istituti Clinici Scientifici Maugeri Centers. The main aims are: Evaluate the prevalence of pain and characterize it in Parkinson's disease and atypical parkinsonisms (MSA) Evaluate the effect of rehabilitation on pain and autonomic symptoms Evaluate the prevalence of autonomic symptoms in Parkinson's disease and atypical parkinsonisms (MSA) Assess the impact of pain and autonomic symptoms on quality of life. Participants will perform neurological examination, rehabilitation program and clinical scales. Researchers will compare the two groups of patients (PD and MSA) and the effect of the rehabilitation on pain, autonomic symptoms and quality of life.

Eligibility

Min Age: 18 Years

Inclusion Criteria2

Clinical diagnosis of Parkinson's Disease or Multiple System Atrophy according to current international criteria (Gilman S et al, 2008; Postuma RB et al. 2015).
Mini-Mental State Examination score at least 10

Exclusion Criteria5

vascular or pharmacological parkinsonism
diabetes mellitus
hepatic or renal dysmetabolism,
hypothyroidism or hyperthyroidism
assumption of potentially neurotoxic drugs

Interventions

OTHERRehabilitation

All patients included in the study will undergo a basic evaluation with a neurological examination, a rehabilitation program to improve strength, coordination, balance, endurance, and the ability to perform activities of daily life.

OTHERAdministration of Clinical scales

All patients included in the study will be evaluated by clinical scales assessing the disease stage, clinical severity, freezing, motor and non-motor impairment, cognitive impairment, depression, quality of life, autonomic dysfunction, pain.