Multiple System Atrophy Clinical Trials

61 recruitingLast updated: June 17, 2026

There are 61 actively recruiting multiple system atrophy clinical trials across 24 countries. Studies span Not Applicable, Phase 1, Phase 2, Early Phase 1, Phase 3. Top locations include Nashville, Tennessee, United States, Boston, Massachusetts, United States, New York, New York, United States. Updated daily from ClinicalTrials.gov.


Multiple System Atrophy Trials at a Glance

61 actively recruiting trials for multiple system atrophy are listed on ClinicalTrialsFinder across 6 cities in 24 countries. The largest study group is Not Applicable with 15 trials, with the heaviest enrollment activity in Nashville, Boston, and New York. Lead sponsors running multiple system atrophy studies include Vanderbilt University Medical Center, Beijing Tiantan Hospital, and Massachusetts General Hospital.

Browse multiple system atrophy trials by phase

Treatments under study

About Multiple System Atrophy Clinical Trials

Looking for clinical trials for Multiple System Atrophy? There are currently 44 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Multiple System Atrophy trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Multiple System Atrophy clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 61 trials

Recruiting
Phase 2

An Extension Trial to Test if TEV-56286 is Effective in Relieving Multiple System Atrophy

Multiple System Atrophy
Teva Branded Pharmaceutical Products R&D LLC200 enrolled26 locationsNCT07197866
Recruiting
Phase 2

A Trial to Test if TEV-56286 is Effective for Treatment of Participants With Multiple System Atrophy

Multiple System Atrophy
Teva Branded Pharmaceutical Products R&D LLC350 enrolled58 locationsNCT06568237
Recruiting

Natural History Study of Synucleinopathies

Multiple System AtrophyParkinson DiseaseDementia With Lewy Bodies+5 more
NYU Langone Health800 enrolled8 locationsNCT01799915
Recruiting
Phase 2

A Phase 2a Study of Foralumab Nasal in Patients With Multiple System Atrophy (MSA)

Multiple System Atrophy
Tiziana Life Sciences LTD5 enrolled1 locationNCT06868628
Recruiting

Prospective Multicenter Registry Study of Multiple System Atrophy in China

Multiple System AtrophyParkinson's DiseaseAtypical Parkinsonism
Peking University First Hospital214 enrolled1 locationNCT07644013
Recruiting
Early Phase 1

Evaluation of [¹⁸F]MODAG-009 PET Imaging in Synucleinopathies

Parkinson DiseaseHealthy AdultMultiple System Atrophy (MSA)
MODAG GmbH13 enrolled1 locationNCT07640555
Recruiting

Multiple System Atrophy Multidisciplinary Clinic

Multiple System Atrophy (MSA)
University of Texas Southwestern Medical Center200 enrolled1 locationNCT03811808
Recruiting
Not Applicable

Individualized Transcranial Magnetic Stimulation in Parkinsonian Disorders

Multiple System AtrophyProgressive Supranuclear PalsyParkinson's Disease
Peking University First Hospital50 enrolled1 locationNCT07570212
Recruiting
Not Applicable

Efficacy and Safety of Transcranial dIrect Current stiMulation in Multiple System Atrophy-Cerebellar Variant

Multiple System Atrophy - Cerebellar Subtype (MSA-C)
University of Salerno30 enrolled1 locationNCT06821256
Recruiting
Phase 2

A Phase 2 Study of YA-101 in Patients With Multiple System Atrophy

Multiple System Atrophy
Dasher Neuroscience Inc.75 enrolled9 locationsNCT06848231
Recruiting
Phase 1

Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of ION464 Administered to Adults With Multiple System Atrophy (HORIZON)

Multiple System Atrophy
Ionis Pharmaceuticals, Inc.40 enrolled15 locationsNCT04165486
Recruiting
Not Applicable

Comprehensive Swallowing Rehabilitation in Patients With MSA

Multiple System Atrophy
Seoul National University Hospital24 enrolled1 locationNCT04782284
Recruiting

Invasive Home Ventilation in Denmark

Spinal Cord Injuries (SCI)Neuromuscular Diseases (NMD)MSA - Multiple System Atrophy+5 more
Rigshospitalet, Denmark450 enrolled1 locationNCT07467187
Recruiting

Pain and Autonomic Symptoms in Parkinson's Disease and Atypical Parkinsonisms

Multiple System AtrophyParkinson Disease
Istituti Clinici Scientifici Maugeri SpA280 enrolled9 locationsNCT05748028
Recruiting
Phase 1

A Phase I/III Clinical Study to Evaluate NouvNeu001 Injection for Multiple System Atrophy

Multiple System Atrophy - Parkinsonian Subtype (MSA-P)
iRegene Therapeutics Co., Ltd.9 enrolled1 locationNCT07289477
Recruiting
Not Applicable

The Swedish BioFINDER 2 Study

DementiaMultiple System AtrophyAlzheimer Disease+10 more
Skane University Hospital2,950 enrolled2 locationsNCT03174938
Recruiting
Not Applicable

CPAP for the Treatment of Supine Hypertension

Multiple System AtrophyParkinson DiseaseAutonomic Failure+3 more
Vanderbilt University Medical Center59 enrolled1 locationNCT05489575
Recruiting
Not Applicable

Ultra-High Resolution PET in Aging, Neurodegeneration and Psychotic Disorders

PSP - Progressive Supranuclear PalsyAlzheimer Dementia (AD)MSA - Multiple System Atrophy+7 more
Universitaire Ziekenhuizen KU Leuven300 enrolled1 locationNCT07509125
Recruiting
Phase 1

Autologous suraL nervE Grafting to the Substantia nigrA in Patients With Synuclienopathies

Multiple System AtrophyParkinsons Disease
Craig van Horne, MD, PhD7 enrolled1 locationNCT06683365
Recruiting

Exploring the Olfactory Mucosa, Blood and Urine for the Identification of Early Biomarkers of Parkinson's Disease, Atypical Parkinsonisms and Neurocognitive Disorders Due to Lewy Body Disease

Parkinson DiseaseMSA - Multiple System AtrophyLewy Body Dementia (LBD)+2 more
Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta180 enrolled3 locationsNCT06846658