Multiple System Atrophy Clinical Trials

40 recruiting

Multiple System Atrophy Trials at a Glance

53 actively recruiting trials for multiple system atrophy are listed on ClinicalTrialsFinder across 6 cities in 24 countries. The largest study group is Not Applicable with 13 trials, with the heaviest enrollment activity in Nashville, Boston, and New York. Lead sponsors running multiple system atrophy studies include Vanderbilt University Medical Center, Teva Branded Pharmaceutical Products R&D LLC, and Min Zhao,MD.

Browse multiple system atrophy trials by phase

Treatments under study

About Multiple System Atrophy Clinical Trials

Looking for clinical trials for Multiple System Atrophy? There are currently 40 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Multiple System Atrophy trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Multiple System Atrophy clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 53 trials

Recruiting
Phase 2

A Phase 2 Study of YA-101 in Patients With Multiple System Atrophy

Multiple System Atrophy
Dasher Neuroscience Inc.75 enrolled9 locationsNCT06848231
Recruiting
Not Applicable

Efficacy and Safety of Transcranial dIrect Current stiMulation in Multiple System Atrophy-Cerebellar Variant

Multiple System Atrophy - Cerebellar Subtype (MSA-C)
University of Salerno30 enrolled1 locationNCT06821256
Recruiting
Phase 1

Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of ION464 Administered to Adults With Multiple System Atrophy (HORIZON)

Multiple System Atrophy
Ionis Pharmaceuticals, Inc.40 enrolled15 locationsNCT04165486
Recruiting
Not Applicable

Comprehensive Swallowing Rehabilitation in Patients With MSA

Multiple System Atrophy
Seoul National University Hospital24 enrolled1 locationNCT04782284
Recruiting
Phase 2

A Trial to Test if TEV-56286 is Effective for Treatment of Participants With Multiple System Atrophy

Multiple System Atrophy
Teva Branded Pharmaceutical Products R&D LLC350 enrolled54 locationsNCT06568237
Recruiting
Phase 2

An Extension Trial to Test if TEV-56286 is Effective in Relieving Multiple System Atrophy

Multiple System Atrophy
Teva Branded Pharmaceutical Products R&D LLC200 enrolled15 locationsNCT07197866
Recruiting

Invasive Home Ventilation in Denmark

Spinal Cord Injuries (SCI)Neuromuscular Diseases (NMD)MSA - Multiple System Atrophy+5 more
Rigshospitalet, Denmark450 enrolled1 locationNCT07467187
Recruiting

Pain and Autonomic Symptoms in Parkinson's Disease and Atypical Parkinsonisms

Multiple System AtrophyParkinson Disease
Istituti Clinici Scientifici Maugeri SpA280 enrolled9 locationsNCT05748028
Recruiting
Phase 1

A Phase I/III Clinical Study to Evaluate NouvNeu001 Injection for Multiple System Atrophy

Multiple System Atrophy - Parkinsonian Subtype (MSA-P)
iRegene Therapeutics Co., Ltd.9 enrolled1 locationNCT07289477
Recruiting
Not Applicable

The Swedish BioFINDER 2 Study

DementiaMultiple System AtrophyAlzheimer Disease+10 more
Skane University Hospital2,950 enrolled2 locationsNCT03174938
Recruiting
Not Applicable

CPAP for the Treatment of Supine Hypertension

Multiple System AtrophyParkinson DiseaseAutonomic Failure+3 more
Vanderbilt University Medical Center59 enrolled1 locationNCT05489575
Recruiting
Phase 1

Autologous suraL nervE Grafting to the Substantia nigrA in Patients With Synuclienopathies

Multiple System AtrophyParkinsons Disease
Craig van Horne, MD, PhD7 enrolled1 locationNCT06683365
Recruiting

Exploring the Olfactory Mucosa, Blood and Urine for the Identification of Early Biomarkers of Parkinson's Disease, Atypical Parkinsonisms and Neurocognitive Disorders Due to Lewy Body Disease

Parkinson DiseaseMSA - Multiple System AtrophyLewy Body Dementia (LBD)+2 more
Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta180 enrolled3 locationsNCT06846658
Recruiting
Phase 1

[18F]F-DOPA Imaging in Patients With Autonomic Failure

Multiple System AtrophyParkinson DiseaseDementia With Lewy Bodies+2 more
Daniel Claassen40 enrolled1 locationNCT04246437
Recruiting

Shanghai Clinical Cohort - Parkinson's Disease (Reserve)

Multiple System AtrophyParkinson's Disease (PD)
Ruijin Hospital700 enrolled1 locationNCT07353463
Recruiting
Phase 3

MSA-01 in Multiple System Atrophy

Multiple System Atrophy (MSA)
Tokyo University140 enrolled12 locationsNCT07446894
Recruiting

Synaptic Loss in Multiple System Atrophy

Multiple System AtrophyProgressive Supranuclear Palsy (PSP)
University of Exeter36 enrolled1 locationNCT05121012
Recruiting

Facilitating Diagnostics and Prognostics of Parkinsonian Syndromes Using Neuroimaging

Multiple System AtrophyParkinson DiseaseProgressive Supranuclear Palsy
University of Texas Southwestern Medical Center90 enrolled1 locationNCT03872102
Recruiting
Not Applicable

Overnight Trials With Heat Stress in Autonomic Failure Patients With Supine Hypertension

HypertensionMultiple System AtrophyAutonomic Failure+1 more
Vanderbilt University Medical Center20 enrolled1 locationNCT03042988
Recruiting
Early Phase 1

Effect of Midodrine vs Abdominal Compression on Cardiovascular Risk Markers in Autonomic Failure Patients

Multiple System AtrophyParkinson DiseaseAutonomic Failure+2 more
Vanderbilt University Medical Center31 enrolled1 locationNCT04620382