Arterial Function Parameters and Transcranial Doppler Velocity in Paediatric Patients With Sickle Cell Disease
The Relationship of Transcranial Doppler Velocity With Other Vascular Measurements in Children With Sickle Cell Anaemia
The University of The West Indies
34 participants
Feb 1, 2023
OBSERVATIONAL
Conditions
Summary
Structural and functional changes in arteries are increasingly being recognized as significant features of sickle cell disease. This study aims to determine whether there are differences in arterial function parameters between children with sickle cell disease with normal and abnormal transcranial Doppler velocity. After informed consent is obtained, participants will have vascular, Transcranial Doppler, haematological and biochemical parameters measured. Researchers will compare children with sickle cell disease who have normal Transcranial Doppler velocity and no history of stroke with children with those who have an abnormal Transcranial Doppler velocity with or without a history of stroke to see if there are significant differences in arterial function parameters.
Eligibility
Inclusion Criteria5
- Pediatric participants with sickle cell anaemia (HbSS, HbSβ0 thalassemia, HbSD, HbSOArab)
- Age: Between 4-16 years of age, at the time of enrolment
- Has had at least one complete TCD study whether or not on hydroxyurea treatment or in a clinical trial.
- Parent or guardian willing and able to provide informed consent and child gives assent
- Ability to comply with study-related evaluations.
Exclusion Criteria4
- Participants who meet any of the following criteria are disqualified from enrollment in the study:
- Patients in whom a TCD study cannot be completed
- Patients who have had an Erythrocyte transfusion in the past two months
- Patients who are acutely ill or have had an acute infection in the past two weeks
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Locations(1)
View Full Details on ClinicalTrials.gov
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NCT05748717