RecruitingNCT05758662

The Effect of Subclinical Leaflet Thrombosis and Prosthesis Type on Transcatheter Aortic Valve Degeneration (POPular PET TAVI)

The Effect of Subclinical Leaflet Thrombosis and Prosthesis Type on Transcatheter Aortic Valve Degeneration

Sponsor

St. Antonius Hospital

Enrollment

180 participants

Start Date

Nov 16, 2023

Study Type

OBSERVATIONAL

Conditions

Aortic Valve Stenosis

Summary

A multicentre cross-sectional cohort study to assess the difference in bioprosthetic micro-calcification activity, detected with 18F-NaF PET-CT, as early marker of transcatheter valve degeneration, between patients with vs. without subclinical leaflet thrombosis at five years after TAVI; and between patients with intra-annular vs. supra-annular TAVI prostheses.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying 18F-sodium fluoride Positron Emission Tomography (18F-NaF PET), Cardiac Computed Tomography (CT), Transthoracic Echocardiography (TTE) for people with aortic valve stenosis. The study is currently recruiting participants at 4 locations. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TEST18F-sodium fluoride Positron Emission Tomography (18F-NaF PET), Cardiac Computed Tomography (CT), Transthoracic Echocardiography (TTE)

Patients undergo a hybrid 18F-NaF-PET CT scan and TTE at five years after TAVI

Locations(4)

Rigshospitalet

Copenhagen, Denmark

St. Antonius Hospital

Nieuwegein, Utrecht, Netherlands

Amsterdam UMC

Amsterdam, Netherlands

University of Edinburgh

Edinburgh, United Kingdom

View Full Details on ClinicalTrials.gov

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NCT05758662

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