Aortic Valve Stenosis Clinical Trials

88 recruitingLast updated: June 18, 2026

There are 88 actively recruiting aortic valve stenosis clinical trials across 37 countries. Studies span Not Applicable, Phase 4, Phase 2, Phase 3. Top locations include Milan, Italy, San Francisco, California, United States, Madrid, Spain. Updated daily from ClinicalTrials.gov.


Aortic Valve Stenosis Trials at a Glance

88 actively recruiting trials for aortic valve stenosis are listed on ClinicalTrialsFinder across 6 cities in 37 countries. The largest study group is Not Applicable with 39 trials, with the heaviest enrollment activity in Milan, San Francisco, and Madrid. Lead sponsors running aortic valve stenosis studies include St. Antonius Hospital, Institut universitaire de cardiologie et de pneumologie de Québec, University Laval, and IRCCS Policlinico S. Donato.

Browse aortic valve stenosis trials by phase

Treatments under study

About Aortic Valve Stenosis Clinical Trials

Looking for clinical trials for Aortic Valve Stenosis? There are currently 77 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Aortic Valve Stenosis trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Aortic Valve Stenosis clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 88 trials

Recruiting
Not Applicable

Comparison of Allegra vs Sapien Transcatheter Aortic Valves in Valve-In-Valve Indication

Aortic Valve StenosisStructural Valve Deterioration
Fundación EPIC104 enrolled11 locationsNCT06049654
Recruiting
Phase 2

Impact of Local Tissue Inflammation on Intramyocardial Conduction Pathways Post Percutaneous Valve : Evaluation by Positron Emission Tomography on Exploratory Cohort

Aortic Valve Stenosis
University Hospital, Brest100 enrolled1 locationNCT05308888
Recruiting

Impact of Trans-catheter Aortic Valve Implantation on Renal Function

Chronic Kidney DiseasesAortic Valve StenosisRenal Failure Acute Chronic
Fondazione Policlinico Universitario Agostino Gemelli IRCCS1,000 enrolled1 locationNCT07626710
Recruiting

Smartphone Based Digital Screening for Aortic Valve Stenosis

Aortic Valve StenosisArtifical Intelligence
Medical University Innsbruck500 enrolled1 locationNCT07284550
Recruiting
Not Applicable

Von Willebrand Factor Point-of-care Testing to Improve Minimally Invasive TAVI Outcomes

Aortic Valve StenosisAortic Valve Insufficiency
University Hospital, Lille944 enrolled9 locationsNCT03728049
Recruiting
Not Applicable

Personalized, CT-guided Antithrombotic Therapy Versus Lifelong Single Antiplatelet Therapy to Reduce Thromboembolic and Bleeding Events in Non-atrial Fibrillation Patients After Transcatheter Aortic Valve Implantation

Severe Aortic Valve Stenosis
St. Antonius Hospital2,500 enrolled1 locationNCT06168370
Recruiting

The Effect of Subclinical Leaflet Thrombosis and Prosthesis Type on Transcatheter Aortic Valve Degeneration (POPular PET TAVI)

Aortic Valve Stenosis
St. Antonius Hospital180 enrolled4 locationsNCT05758662
Recruiting
Not Applicable

CAPTURE-2: Controlled Arterial Protection to Ultimately Remove Embolic Material

Aortic Valve DiseaseAortic StenosisAortic Valve Stenosis
EmStop Inc663 enrolled2 locationsNCT07276711
Recruiting

REdo Transcatheter Aortic VALVE Implantation for the Management of Transcatheter Aortic Valve Failure

Aortic Valve Stenosis
The Leeds Teaching Hospitals NHS Trust550 enrolled69 locationsNCT06557798
Recruiting
Not Applicable

Post-Dilatation in Balloon-Expandable TAVI Prostheses

Aortic Valve Stenosis
Medical University of Vienna146 enrolled1 locationNCT07477002
Recruiting
Not Applicable

Structured Shared Decision Making for Patients Undergoing SAVR or TAVR

Aortic Valve StenosisSymptomatic Aortic Stenosis
Insel Gruppe AG, University Hospital Bern140 enrolled1 locationNCT05711186
Recruiting
Phase 2Phase 3

Ataciguat for Slowing the Progression of Moderate Calcific Aortic Valve Stenosis: A Randomized, Placebo Controlled Study

Moderate Aortic Valve Stenosis
Kardigan, Inc.1,276 enrolled70 locationsNCT07001800
Recruiting

Hydra Single-centre Experience - Copenhagen, Denmark

Aortic Valve Stenosis
Sahajanand Medical Technologies Limited50 enrolled1 locationNCT06342635
Recruiting

Hydra Registry - UK

Aortic Valve Stenosis
Sahajanand Medical Technologies Limited250 enrolled4 locationsNCT06507579
Recruiting

Hydra Registry - Italy Experience

Aortic Valve Stenosis
Sahajanand Medical Technologies Limited500 enrolled4 locationsNCT05956652
Recruiting
Phase 4

Patient Quality of Recovery After TAVR With Different Sedation Regimens

Aortic Valve StenosisTranscatheter Aortic Valve Replacement (TAVR)
David Lyubashevsky126 enrolled1 locationNCT07556523
Recruiting

Ischemic And Bleeding Risk Assessment After TAVR

Aortic Valve StenosisTranscatheter Aortic Valve Replacement
Niguarda Hospital2,500 enrolled12 locationsNCT06000943
Recruiting

COronary Re-engageMent aFter randOm NavitoR alignmenT (COMFORT STUDY)

Aortic Valve StenosisTranscatheter Aortic Valve Replacement
Niguarda Hospital100 enrolled1 locationNCT05779787
Recruiting

Detecting Changes in Arterial Blood Volume and Cardiac Efficiency

Aortic Valve Stenosis
HemoCept Inc.20 enrolled1 locationNCT07205341
Recruiting

Impact of Transcatheter Aortic Valve Implantation and Mitral Valve Repair on Sleep-Disordered Breathing

Sleep-disordered breathing (SDB)Aortic Valve StenosisMitral Valve Regurgitation
Aristides Plaitis150 enrolled1 locationNCT07520656