Screening for Lung Cancer in Subjects With Family History of Lung Cancer
The University of Hong Kong
1,520 participants
Feb 1, 2023
OBSERVATIONAL
Conditions
Summary
Lung cancer can be detected via screening of high-risk individuals, i.e current or ex-heavy smokers, with low-dose computer tomography (LDCT) of thorax. The National Lung Screening Trial in US and the NELSON trial in Europe demonstrated reduction in lung cancer mortality with LDCT screening for lung cancer. In Hong Kong, however, there is a prominence of female never-smokers with lung cancer. There is no identifiable risk factors for non-smokers with lung cancer except family history of lung cancer. The hypothesis is that lung cancer screening for subjects with family history of lung cancer, can detect early lung cancer.
Eligibility
Inclusion Criteria3
- Age 50-75, men or women, smokers or non-smokers
- Being first degree relatives (Siblings, children, and parents) of lung cancer subjects
- Having no known lung cancer before
Exclusion Criteria2
- Non-Chinese
- Mentally incompetent to give informed consent
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Interventions
A multi-detector row CT scanner with minimum section collimation of ≤1 mm and minimum number of data acquisition channels ≥ 16will be employed.
Control subjects will also proceed to CT thorax, and outcome measures be compared to subjects
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT05762731