RecruitingNCT05763966

Uppsala Psychosis Cohort

Uppsala Psychosis Cohort: a Multimodal Study in Early Stage Psychosis Patients, High Risk Individuals and Healthy Controls

Sponsor

Uppsala University

Enrollment

120 participants

Start Date

Apr 1, 2023

Study Type

OBSERVATIONAL

Conditions

Schizophrenia; Psychosis

Summary

A multimodal longitudinal study in early stage psychosis patients and individuals at high risk for psychosis. Healthy controls are included for baseline comparisons. The aim is to investigate disease mechanisms of psychotic disorders, specifically focusing on the synaptic pruning hypothesis.

Eligibility

Min Age: 18 YearsMax Age: 40 Years

Plain Language Summary

Simplified for easier understanding

This study is building a research cohort (a group followed over time) in Uppsala, Sweden, to better understand psychosis — including early-stage psychosis and those at high risk of developing it. It aims to track outcomes, identify biomarkers, and improve early diagnosis and treatment. **You may be eligible if...** - You have a first episode of psychosis (such as schizophrenia, brief psychosis, or schizoaffective disorder, diagnosed using DSM-5), with symptoms starting no more than 3 years ago, OR - You are at clinical high risk for developing psychosis, based on structured interview assessment (SIPS) **You may NOT be eligible if...** - Another major psychiatric illness (like bipolar disorder, severe depression, or autism) appears to be causing your current psychotic symptoms - You are on long-term benzodiazepine use that you cannot stop briefly during the study - You have intellectual disability (IQ below 70) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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