RecruitingNot ApplicableNCT06341517

Brain Circuitry Therapeutics for Schizophrenia

Brain Circuitry Therapeutics for Schizophrenia - A Cross-species Longitudinal Randomized Controlled Clinical Study to Treat Negative Symptoms of Schizophrenia Using Non-invasive Stimulation of the Cerebellum


Sponsor

Indrit Begue

Enrollment

70 participants

Start Date

Apr 15, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

This project is a double blind randomized clinical trials that examines the efficacy of cerebellar non invasive stimulation for apathy improvement in patients with schizophrenia


Eligibility

Min Age: 18 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether targeted brain stimulation (a technique called TMS — transcranial magnetic stimulation) can improve symptoms in people with schizophrenia or related conditions by targeting specific brain circuits. Participants continue their regular medications during the study. **You may be eligible if...** - You are between 18 and 65 years old - You have been diagnosed with schizophrenia, schizoaffective disorder, or a related psychotic condition - Your condition is clinically stable and your antipsychotic medication has not changed for at least 4 weeks - You have not been hospitalized in a psychiatric unit in the past 3 months **You may NOT be eligible if...** - You are currently experiencing active hallucinations or delusions - You have a significant ongoing major depressive episode - You have a history of fainting or seizures - You have metal implants in your head, a pacemaker, cochlear implant, or deep brain stimulator - You use cocaine or other substances daily - You have significant movement side effects from your medications - You are pregnant Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEiTBS

Intermittent Theta Burst Stimulation (iTBS) pattern consisting of 2 s trains of 3 pulses at 50 Hz, repeated at 5 Hz, every 10s for a total of 600 pulses for up to 8 sessions daily for 5 days


Locations(2)

Campus Biotech

Geneva, Switzerland

Indrit Bègue

Geneva, Switzerland

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NCT06341517


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