RecruitingPhase 4NCT05764733

Bone, Exercise, Alendronate, and Caloric Restriction

The Bone, Exercise, Alendronate, and Caloric Restriction Trial


Sponsor

Wake Forest University Health Sciences

Enrollment

900 participants

Start Date

Jun 8, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this research is to identify strategies that minimize bone loss that occurs when older adults lose weight. Participation in this research will involve up to nine assessment visits and last up to two years.


Eligibility

Min Age: 60 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Bisphosphonate, Placebo, and others for people with bone loss. The study is currently recruiting participants at 2 locations. People eligible for this study include aged 60 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGBisphosphonate

Medicine used to treat bone problems, called osteopenia or osteoporosis.

BEHAVIORALResistance Training/Bone-Loading Exercise

Exercise in small groups three days per week under the supervision of exercise physiologists. Heart rate and blood pressure will be measured before and after each session and participants will warm-up by walking or cycling for five minutes at a slow pace. All RT exercises will be conducted on machines which accommodate different body sizes and allow small increments in resistance, both important considerations for low functioning older adults with obesity.

OTHERPlacebo

Capsules identical to the active alendronate capsules without any active ingredients with the same dosing and follow up as BIS treatment group.


Locations(2)

University of Colorado Anschutz Medical Campus

Aurora, Colorado, United States

Atrium Health Wake Forest Baptist Medical Center

Winston-Salem, North Carolina, United States

View Full Details on ClinicalTrials.gov

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NCT05764733


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