RecruitingNot ApplicableNCT05765110

SPEECH as Biomarker for Emotion, Movement and cOgnition in Parkinson's Disease


Sponsor

Insel Gruppe AG, University Hospital Bern

Enrollment

80 participants

Start Date

Jan 3, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

With this study, the investigators want to investigate whether computerized speech analysis can be used to reliably and objectively detect motor, emotional, and cognitive fluctuations in Parkinson's disease patients.


Eligibility

Min Age: 30 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is exploring whether speech patterns can serve as a biomarker — a measurable signal — for tracking emotions, movement, and thinking ability in people with Parkinson's disease. Changes in speech may reflect changes in brain function and could eventually help monitor disease progression remotely. **You may be eligible if...** - You are 30–75 years old - You have been diagnosed with idiopathic Parkinson's disease (the most common form) - You speak German or French fluently - You may or may not have a deep brain stimulation implant **You may NOT be eligible if...** - You have speech difficulties caused by something other than Parkinson's disease (e.g., stroke) - You have been diagnosed with aphasia (a language disorder) - You have another brain condition such as atypical Parkinsonism, Alzheimer's disease, multiple sclerosis, epilepsy, or dementia - You have significant cognitive impairment (MoCA score below 24) or severe depression with suicidal thoughts Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERDopaminergic OFF drug state

Experiment will be performed without dopaminergic medication

OTHERDBS OFF state

Turning off the stimulation during experiment

OTHERDopaminergic ON drug state

Experiment will be performed with dopaminergic medication

OTHERDBS ON state

Experiment will be performed with stimulation (ON condition)


Locations(2)

Czech Technical University Prague

Prague, Czechia

University Hospital Inselspital, Berne

Bern, Switzerland

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NCT05765110


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