RecruitingNCT05768399

The Role of Biomarkers in the Occurrence and Development of Asthma

Sponsor

Children's Hospital of Chongqing Medical University

Enrollment

2 participants

Start Date

Jul 4, 2023

Study Type

OBSERVATIONAL

Conditions

Asthma in Children

Summary

To study the expression level of biomarkers such as GITRL in peripheral blood of children with asthma and analyze their correlation with the severity of asthma. To study the predictive value of biomarkers level for the occurrence and development of asthma. And to provide supplementary detection means and predictive indicators for the diagnosis of asthma and the severity of asthma.

Eligibility

Min Age: 4 YearsMax Age: 12 Years

Inclusion Criteria5

In line with the diagnostic criteria in the Guidelines for the Diagnosis and Prevention of Bronchial Asthma in Children (2016 Edition)
Age: 4-12 years old for new diagnosis or recurrent episodes
Typical clinical manifestations and complete clinical data
Family members or guardians of children with informed research and signed consent
All healthy control subjects had no history of lung disease, allergic rhinitis or any other atopic disease

Exclusion Criteria5

Suffering from other respiratory diseases (such as bronchiectasis, allergic rhinitis, respiratory failure, tuberculosis, obstructive airway disease) or other inflammatory diseases.
Abnormal development of congenital airway and lung tissue
History of immunosuppressant or glucocorticoid use in the first 4 weeks
Suffering from other endocrine system and immune system diseases
Incomplete clinical data or examinations.

Interventions

DIAGNOSTIC_TESTThe level of biomarkers in Peripheral blood

All participants will be extracted 5ml peripheral blood into the anticoagulant tube by nurses and the peripheral blood will be detected for biomarkers of asthma. Children with asthma will take pulmonary function, blood test and specific IgE test etc. The lung function test will be performed by professional technicians and the results will be interpreted by specialists. The blood test and specific IgE test will be collected by specialist nurses and the results will be issued by professional inspectors. Children with asthma and their guardians will be asked for filling the questionnaire of Childhood Asthma Control Test (C-ACT). And then the doctor will check and calculate the scores after completion.