RecruitingNot ApplicableNCT06044051

Dynamics of the Upper and Lower Airway Respiratory Microbiomes Associated With Severe Infant Asthma

Dynamique Des Microbiomes Respiratoires Des Voies supérieures et inférieures associée à l'Asthme sévère Des Nourrissons

Sponsor

University Hospital, Rouen

Enrollment

100 participants

Start Date

Sep 26, 2023

Study Type

INTERVENTIONAL

Conditions

Asthma Asthma in Children

Summary

Nature of potential dysbiosis, interrelation of the different microbiomes of the respiratory tract, and potential role of the immune system in the pathogenesis of severe asthma in infants, and its evolution under treatment. Exploring and understanding these data is to improve patient care and discover new therapeutic targets. The aim is to open up prospects for therapeutic studies, such as the use of azithromycin as an immunomodulator in infant asthma, the results of which are discordant.

Eligibility

Max Age: 24 Months

Plain Language Summary

Simplified for easier understanding

This study tracks how bacteria and other microorganisms in the nose, throat, and lungs (the respiratory microbiome) change over time in patients undergoing treatment for respiratory conditions. Understanding these changes may help doctors predict complications and improve treatment strategies. **You may be eligible if...** - You have a respiratory condition being treated in this study - You are willing to provide airway samples (such as nasal swabs or sputum) at multiple time points **You may NOT be eligible if...** - You have conditions that make it unsafe to collect airway samples - You are not able to complete follow-up visits Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERBlood sample

An additionnal volume of blood will be collected at inclusion and at each follow-up visit

OTHERExpectoration

Expectoration will be collected at inclusion and at each follow-up visit

OTHERNasopharyngeal swab

A nasopharyngeal swab will be collected at inclusion and at each follow-up visit after an induced sputum

Locations(1)

Rouen University Hospital

Rouen, France

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NCT06044051

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