RecruitingNot ApplicableNCT05768763

SEARCH SAPPHIRE Phase B

SEARCH Multisectoral Strategy to Address Persistent Drivers of the HIV Epidemic in East Africa Phase B

Sponsor

University of California, San Francisco

Enrollment

80,000 participants

Start Date

Mar 28, 2023

Study Type

INTERVENTIONAL

Conditions

HIV

Summary

This study will evaluate the effects of optimized dynamic prevention and treatment packages delivered in a precision community health model on HIV incidence, as well as other health outcomes, in a community randomized trial design.

Eligibility

Min Age: 15 Years

Plain Language Summary

Simplified for easier understanding

This trial is studying the health and wellbeing of communities in East Africa (Kenya and Uganda) as part of an ongoing public health research program. You may be eligible if: you are 15 years or older; you live in one of the SEARCH study communities; and you are able to provide informed consent (or have a parent or guardian provide consent if required by your country). You may NOT be eligible if: you are under 15 years old; you do not live in a SEARCH study community; or you are not able to give consent yourself or through a parent or guardian. Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALCommunity-enhanced reach activities

We will conduct a series of community engagement activities designed to reach persons at risk for HIV, undiagnosed with HIV or diagnosed, or hypertension, and fallen out of care, working closely with community health workers, integrated in the community health system.

BEHAVIORALPerson-centered care delivery

Structured approach to provide patient-centered biomedical options for HIV prevention (dynamic choice prevention). Tailored services for HIV treatment support using structured life stage evaluation and assessment plan (LEAP) for youth, pregnant women, and persons with or at risk of HIV viral non-suppression, that includes counselling for heavy alcohol users. Structured approach to offer telehealth for severe hypertension follow up.

OTHERData system enhancement to improve reach and person-centered delivery

Both community-enhanced reach and person-centered delivery will be strengthened through a customized in-country Ministry of Health-compatible community health worker smartphone app and two-way data system linking community health workers and clinical records.

BEHAVIORALStandard of Care

Standard of Care in Uganda and Kenya

Locations(2)

SEARCH Office / GPRT

Kisumu, Kenya

Infectious Diseases Research Collaboration

Kampala, Uganda

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NCT05768763

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