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RecruitingNot ApplicableNCT05772845

Vaping and Smoking Withdrawal Project

A Controlled Evaluation of Abstinence-Induced Withdrawal and Motivation to Vape/Smoke Among Daily ENDS Users vs. Cigarette Smokers

Sponsor

State University of New York at Buffalo

Enrollment

370 participants

Start Date

Feb 14, 2023

Study Type

INTERVENTIONAL

Conditions

Acute Abstinence From Cigarettes vs E-cigarettes (ENDS)

Summary

The proposed research, which will systematically and comprehensively characterize the withdrawal among daily vapers compared to daily smokers of combustible cigarettes, filling critical gaps in the understanding of electronic nicotine delivery systems (ENDS) dependence/abuse liability and contributing to the development of therapies for tobacco/nicotine use, the leading preventable cause of death in the US.

Eligibility

Min Age: 21 YearsMax Age: 50 Years

Inclusion Criteria2

  • + months of daily/near-daily nicotine vaping and/or cigarette smoking (to yield 160 vapers, 160 smokers, 50 dual users)
  • + ng/mL cotinine on a commercially-available quick screen

Exclusion Criteria9

  • intention to quit daily/near-daily vaping/smoking in the next month
  • current (2+ days out of the past 7) use of pipe tobacco, hookah/shisha, smokeless tobacco, dissolvable tobacco, nicotine pouches. For vaping group only, current (2+ days out of past 7) use of cigars, cigarillos, or filtered cigars that are filled with tobacco or a mix of tobacco and marijuana
  • current use of any smoking cessation medication
  • current severe substance dependence other than tobacco/nicotine (including cannabis; NIDA Modified ASSIST of 27+)
  • current (past 2 weeks) suicidal ideation with intent and/or plan
  • current antipsychotic medications or lifetime history of schizophrenia or bipolar disorder
  • pregnancy (intake urine screen)
  • alcohol: AUDIT > 15 for males and >13 for females (eliminated 7/25/23)
  • current major depression (PHQ-9>11) (eliminated 7/25/23)

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Interventions

BEHAVIORALAcute (24-hour) abstinence

Participants will be asked to abstain from all tobacco/nicotine for 24 hours prior to the visit

BEHAVIORALAd libitum smoking/vaping

Participants will be asked to smoke/vape as usual during the 24 hours prior to the visit

Locations(1)

University at Buffalo

Buffalo, New York, United States

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NCT05772845

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