Vaping and Smoking Project in People With Schizophrenia

This study is examining the effects of daily nicotine vaping compared to daily cigarette smoking in people who have schizophrenia. The goal is to better understand how these two forms of nicotine use affect health, brain function, and symptoms in this population. **You may be eligible if...** - You vape or smoke cigarettes daily or nearly daily for at least 6 months - A nicotine test (cotinine level) shows you are actively using nicotine regularly - Your antipsychotic medication dose has been stable for at least 6 months **You may NOT be eligible if...** - You are planning to quit vaping or smoking within the next month - You regularly use other tobacco products like pipes, hookah, smokeless tobacco, or nicotine pouches - If assigned to the vaping group: you also regularly smoke cigars or other tobacco products - You use nicotine in forms that would make it hard to separate the effects of vaping versus smoking Talk to your doctor to see if this trial is right for you.