RecruitingNCT05774834

Neural Bases of Decision-making in Healthy Individuals

A Non-interventional Functional Magnetic Resonance Imaging (fMRI) Study on the Neural Bases of Decision-making in Healthy Individuals


Sponsor

Istituti Clinici Scientifici Maugeri SpA

Enrollment

150 participants

Start Date

Nov 10, 2018

Study Type

OBSERVATIONAL

Conditions

Summary

The goal of this single center non-interventional fMRI study is to assess the neural bases of decision-making and executive functioning in healthy individuals,and whether/how their responsiveness is modulated by ageing. The main questions it aims to answer are: 1. are there specific neural correlates for ageing effects on executive functioning (particularly inhibitory control) and decision-making? 2. Is there a relationship, at the behavioral and neural levels, between ageing-related changes in executive functioning and decision-making? Healthy participants will be recruited for 1. a behavioral assessment including multiple tests of decision-making and executive functioning/inhibitory control; 2. a fMRI session to collect data concerning a) brain activity associated with decision-making and executive functioning, b) brain structural morphometriy (grey-matter volume/density), and c) brain structural connectivity (diffusion weighted imaging). Results will provide an useful baseline for investigating alterations of decision-making and executive functioning, and of their neural bases, in pathological conditions.


Eligibility

Min Age: 18 YearsMax Age: 60 Years

Inclusion Criteria2

  • Healthy participants, as determined by screening assessments and principal investigator judgment
  • The participant must be able to comply with study requirements as judged by the principal investigator

Exclusion Criteria3

  • Any history of alcohol and/or drug abuse, addiction or suspicion of regular consumption of drugs of abuse
  • Use of any psychoactive medication, or medications known to have effect on central nervous system (CNS) or blood flow
  • Any contraindications for magnetic resonance imaging (MRI) scans or any brain/head abnormalities restricting MRI eligibility

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Interventions

OTHERNo intervention

No intervention


Locations(1)

Istituti Clinici Scientifici Maugeri SpA

Pavia, Ita, Italy

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NCT05774834


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