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Healthy Volunteers Clinical Trials

237 recruitingLast updated: June 6, 2026

There are 237 actively recruiting healthy volunteers clinical trials across 39 countries. Studies span Phase 1, Not Applicable, Phase 2, Early Phase 1, Phase 3, Phase 4. Top locations include Bethesda, Maryland, United States, Baltimore, Maryland, United States, Melbourne, Victoria, Australia. Updated daily from ClinicalTrials.gov.


Healthy Volunteers Trials at a Glance

237 actively recruiting trials for healthy volunteers are listed on ClinicalTrialsFinder across 6 cities in 39 countries. The largest study group is Phase 1 with 116 trials, with the heaviest enrollment activity in Bethesda, Baltimore, and Melbourne. Lead sponsors running healthy volunteers studies include Hospices Civils de Lyon, Bristol-Myers Squibb, and AbbVie.

Browse healthy volunteers trials by phase

Treatments under study

About Healthy Volunteers Clinical Trials

Looking for clinical trials for Healthy Volunteers? There are currently 212 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Healthy Volunteers trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Healthy Volunteers clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 237 trials

Recruiting
Phase 2

Effects of Sucralose on Drug Absorption and Metabolism (The SweetMeds Study)

Healthy VolunteersOverweight
National Institute on Alcohol Abuse and Alcoholism (NIAAA)150 enrolled1 locationNCT03407079
Recruiting

Evaluation of Patients With Mood and Anxiety Disorders and Healthy Volunteers

DepressionHealthy VolunteersAnxiety Disorders+2 more
National Institute of Mental Health (NIMH)16,000 enrolled1 locationNCT00024635
Recruiting

Children s Growth and Behavior Study

ObesityHealthy VolunteersEating Behaviors
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)1,500 enrolled1 locationNCT02390765
Recruiting

Collection of Tissue Specimens From Patients With Solid Tumors or Blood Disorders and Their HLA-Compatible Family Members

NeoplasmsHealthy VolunteersHematologic Neoplasms
National Heart, Lung, and Blood Institute (NHLBI)6,000 enrolled1 locationNCT00071045
Recruiting
Not Applicable

New Heart Imaging Techniques to Evaluate Possible Heart Disease

ObesityHealthyDiabetes+2 more
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)4,000 enrolled1 locationNCT01399385
Recruiting
Phase 2

Neurobiology of Suicide

DepressionHealthy Volunteers
National Institute of Mental Health (NIMH)325 enrolled1 locationNCT02543983
Recruiting

Apheresis to Obtain Plasma or White Blood Cells for Laboratory Studies

Healthy VolunteersHIV
National Institute of Allergy and Infectious Diseases (NIAID)3,000 enrolled1 locationNCT00114647
Recruiting
Phase 1

A Research Study Investigating the Effect of NNC0497-0040 in Healthy Participants, Participants With Overweight or Obesity, and Participants With Type 1 Diabetes With Overweight or Obesity

ObesityHealthy VolunteersOverweight+1 more
Novo Nordisk A/S146 enrolled1 locationNCT07578584
Recruiting

Physical and Behavioral Traits of Overweight and Obese Adults

ObesityHealthy Volunteers
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)2,000 enrolled1 locationNCT00428987
Recruiting

Genetic and Epigenetic Signatures of Translational Aging Laboratory Testing (GESTALT)

Healthy VolunteersFrailNon-Healthy/Non-Frail
National Institute on Aging (NIA)900 enrolled1 locationNCT02339012
Recruiting
Not Applicable

Sociocultural & Biobehavioral Influences on Pain Expression and Assessment

PainHealthy VolunteersNormal Physiology
National Center for Complementary and Integrative Health (NCCIH)700 enrolled1 locationNCT03258580
Recruiting

Collection and Analysis of Blood, Bone Marrow, and Buccal Mucosa Samples From Healthy Volunteers

Healthy Volunteers
National Heart, Lung, and Blood Institute (NHLBI)1,000 enrolled1 locationNCT00442195
Recruiting
Not Applicable

A New Generation of Magnetoencephalographs for High Speed Functional Brain Imaging

Healthy VolunteersMild Concussion
Hospices Civils de Lyon80 enrolled2 locationsNCT06244472
Recruiting

Cytapheresis of Volunteer Donors

Healthy Volunteers
National Institute on Aging (NIA)10,000 enrolled1 locationNCT00104325
Recruiting
Phase 1

Safety and Tolerability of ZE74-0282 in Healthy Volunteers

Healthy Volunteers
Eilean Therapeutics AU Pty Ltd40 enrolled1 locationNCT07527221
Recruiting
Not Applicable

Mechanism of Non-invasive Magnetic Stimulation

Healthy Volunteers
National Institute on Drug Abuse (NIDA)70 enrolled1 locationNCT03394066
Recruiting
Phase 1

Developing Biomarkers of Dietary Intake: Dose Dependent Measurement of Sugar Intake

Healthy VolunteersDiet Therapy
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)60 enrolled1 locationNCT04799301
Recruiting

Studies of Dermatologic Diseases Biospecimen Acquisition Protocol

Healthy VolunteersCarcinoma, Merkel CellDermatologic Conditions+1 more
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)700 enrolled1 locationNCT02471352
Recruiting
Early Phase 1

Human Milk Oligosaccharide-Based Synbiotic Supplement for Intestinal Microbiota Dysbiosis

Healthy Volunteers
National Heart, Lung, and Blood Institute (NHLBI)100 enrolled1 locationNCT06615986
Recruiting
Phase 1

A Dose-Escalation Study of RO7875913 in Healthy Participants

Healthy Volunteers
Genentech, Inc.40 enrolled1 locationNCT07342114