RecruitingNCT05778253

The Role of ctDNA Testing Plus AI-based Pathology in Resectable LSCC

Circulating Tumor DNA (ctDNA) Dynamic Monitoring Plus Artificial Intelligence (AI)-Based Pathology Predict the Efficacy of Chemoimmunotherapy in Resectable Lung Squamous Cell Carcinoma (LSCC)


Sponsor

Second Xiangya Hospital of Central South University

Enrollment

50 participants

Start Date

Mar 23, 2023

Study Type

OBSERVATIONAL

Conditions

Summary

The goal of this observational study is to explore whether ctDNA dynamic monitoring plus AI-based pathology can more effectively predict the therapeutic effect of neoadjuvant chemoimmunotherapy for resectable lung squamous cell carcinoma, so as to accurately guide clinical diagnosis and treatment.


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating new ways to detect and monitor lung squamous cell carcinoma — a type of lung cancer — using two cutting-edge technologies: a blood test that detects cancer DNA (ctDNA) and an AI-powered analysis of tissue samples. The goal is to find better tools for predicting outcomes and guiding treatment decisions after surgery. **You may be eligible if:** - You have been diagnosed with lung squamous cell carcinoma confirmed by biopsy or tissue analysis - You are between 18 and 75 years old - You have not yet received any treatment for this cancer - Your cancer is at a stage that may be surgically removable (stage II–IIIb) - Your general health is good (ECOG score 0–1) - Sufficient tissue and blood samples are available for research **You may NOT be eligible if:** - You are unable to understand or participate in the study - You do not meet health or staging requirements for surgery Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTWES and ctDNA detection

WES and ctDNA detection


Locations(1)

Department of Thoracic Surgery, Second Xiangya Hospital of Central South University, China

Changsha, Hunan, China

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NCT05778253


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