RecruitingNot ApplicableNCT05785026

Menthol for Dyspnea Relief in Health and COPD

Effectiveness and Mechanisms of Menthol Inhalation for the Relief of Dyspnea in Health and COPD


Sponsor

KU Leuven

Enrollment

120 participants

Start Date

Jan 1, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

Menthol inhalation (MI) is a novel and promising treatment option for acute relief of dyspnea, however, the underlying ventilatory and/or neural related mechanisms for this relief in symptoms remain unknown. The overall aim of this research project is to systematically examine the mechanisms of dyspnea relief from MI in healthy individuals and those with COPD.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether inhaling menthol can help relieve the sensation of breathlessness (dyspnea) in healthy people and in people with COPD (chronic obstructive pulmonary disease). Menthol is thought to activate cooling receptors in the airways that may reduce the perception of difficulty breathing. **You may be eligible if (healthy participants):** - You are 18 or older - You have normal lung function and are a non-smoker or have been smoke-free for at least 12 months - You can read and understand Dutch or English **You may be eligible if (COPD participants):** - You have clinically stable COPD (no recent exacerbations requiring antibiotics or steroids in the past 14 days) - You meet the same age and language requirements **You may NOT be eligible if:** - You have active COPD symptoms requiring recent medical treatment - You are a current smoker - You have other lung conditions that could interfere with the study Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERMenthol inhalation

300 milligrams of L-menthol will be deposited on to a cellulose swab and secured inside the lower portion of a sealed facemask.

OTHERStrawberry scent

600 microliters of 100% natural strawberry flavoring will be deposited onto on to a cellulose swab and secured inside the lower portion of a sealed facemask.

OTHERMenthol inhalation and facial airflow

Menthol will be administered using a noseplug and facial airflow will be applied with a tabletop fan.

OTHERStrawberry scent and airflow to leg

Strawberry will be administered using a noseplug and airflow to the leg will be applied with a tabletop fan.

OTHERMenthol inhalation and airflow to leg

Menthol will be administered using a noseplug and airflow to the leg will be applied with a tabletop fan.

OTHERStrawberry inhalation and facial airflow

Strawberry will be administered using a noseplug and facial airflow will be applied with a tabletop fan.


Locations(1)

University Hospital Leuven

Leuven, Belgium

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NCT05785026


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