Fecal Microbial Transplantation for Rheumatoid Arthritis Trial

This study is testing whether fecal microbiota transplantation (FMT) — transplanting stool from a healthy donor — can help people with rheumatoid arthritis (RA) who are currently in remission or have low disease activity. Researchers believe gut bacteria may play a role in autoimmune diseases like RA and want to test whether changing the gut microbiome can extend remission. **You may be eligible if...** - You are 18 or older with a confirmed diagnosis of rheumatoid arthritis - You test positive for RA antibodies (ACPA and/or rheumatoid factor) - Your RA medications have been stable for more than 6 months - Your disease is currently in remission or at low activity **You may NOT be eligible if...** - You are pregnant or breastfeeding - You have recently (within 60 days) used high-dose steroids, IV steroids, biologic therapies, or JAK inhibitors - You have a diagnosed immune deficiency (HIV, transplant history, or other autoimmune diseases requiring treatment) - You have had a gastrointestinal infection or antibiotic treatment recently Talk to your doctor to see if this trial is right for you.